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Target
Neprilysin
Ligand
BDBM50197519
Substrate
n/a
Meas. Tech.
ChEMBL_432271 (CHEMBL914049)
pH
7±n/a
IC50
4.6±n/a nM
Comments
extracted
Citation
 Pryde, DC; Cook, AS; Burring, DJ; Jones, LH; Foll, S; Platts, MY; Sanderson, V; Corless, M; Stobie, A; Middleton, DS; Foster, L; Barker, L; Van Der Graaf, P; Stacey, P; Kohl, C; Coggon, S; Beaumont, K Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Bioorg Med Chem 15:142-59 (2006) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11
Type:
Enzyme
Mol. Mass.:
85505.38
Organism:
Homo sapiens (Human)
Description:
P08473
Residue:
750
Sequence:
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
  
Inhibitor
Name:
BDBM50197519
Synonyms:
(S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric acid | CHEMBL224670
Type:
Small organic molecule
Emp. Form.:
C21H30FNO4
Mol. Mass.:
379.4656
SMILES:
COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(F)cc1)C(O)=O
Structure:
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