Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50038011
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50156061BDBM50156061(Pyridine-2-carboxylic acid [4-chloro-2-(1,3-dioxo-...)
Affinity DataEC50:  250nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50156061BDBM50156061(Pyridine-2-carboxylic acid [4-chloro-2-(1,3-dioxo-...)
Affinity DataEC50:  250nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50156070BDBM50156070(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  250nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202121BDBM50202121(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  260nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202144BDBM50202144(N-(4-chloro-2-((4-ethoxy-1,3-dioxoisoindolin-2-yl)...)
Affinity DataEC50:  280nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202140BDBM50202140(N-(4-chloro-2-((5-fluoro-1,3-dioxoisoindolin-2-yl)...)
Affinity DataEC50:  330nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202133BDBM50202133(N-(4-bromo-2-((4-ethoxy-1,3-dioxoisoindolin-2-yl)m...)
Affinity DataEC50:  720nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50156082BDBM50156082(N-(4-bromo-2-((1,3-dioxoisoindolin-2-yl)methyl)phe...)
Affinity DataEC50:  750nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202136BDBM50202136(N-(4-bromo-2-((5-fluoro-1,3-dioxoisoindolin-2-yl)m...)
Affinity DataEC50:  930nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202120BDBM50202120(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202134BDBM50202134(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202130BDBM50202130(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202143BDBM50202143(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202135BDBM50202135(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202121BDBM50202121(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202118BDBM50202118(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202128BDBM50202128(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50156070BDBM50156070(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202142BDBM50202142(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202131BDBM50202131(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50156082BDBM50156082(N-(4-bromo-2-((1,3-dioxoisoindolin-2-yl)methyl)phe...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202124BDBM50202124(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202127BDBM50202127(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202123BDBM50202123(N-(2-((1,3-dioxoisoindolin-2-yl)methyl)-4-methoxyp...)
Affinity DataEC50:  1.40E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202130BDBM50202130(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202135BDBM50202135(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202126BDBM50202126(N-(2-((1,3-dioxoisoindolin-2-yl)methyl)-4-fluoroph...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202119BDBM50202119((E)-N-(4-chloro-2-(3-oxo-3-phenylprop-1-enyl)pheny...)
Affinity DataEC50:  1.70E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202143BDBM50202143(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  1.90E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202120BDBM50202120(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  2.10E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202117BDBM50202117(N-(4-chloro-2-((4,5-dimethyl-1,3-dioxoisoindolin-2...)
Affinity DataEC50:  2.20E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202134BDBM50202134(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  2.30E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202122BDBM50202122(N-(4-chloro-2-(3-oxo-3-phenylpropyl)phenyl)picolin...)
Affinity DataEC50:  4.50E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202118BDBM50202118(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  5.70E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202131BDBM50202131(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  5.70E+3nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202139BDBM50202139(N-(2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)pico...)
Affinity DataEC50:  1.39E+4nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202127BDBM50202127(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50:  3.50E+4nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202125BDBM50202125(N-(4-bromo-2-((4,5-dimethyl-1,3-dioxoisoindolin-2-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202124BDBM50202124(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202128BDBM50202128(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202132BDBM50202132(N-(4-chloro-2-((4,5-dimethoxy-1,3-dioxoisoindolin-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202142BDBM50202142(N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)ph...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202129BDBM50202129(N-(4-bromo-2-((4,5-dimethoxy-1,3-dioxoisoindolin-2...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202137BDBM50202137(N-(2-((1,3-dioxoisoindolin-2-yl)methyl)-3-fluoroph...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50202141BDBM50202141(N-(4-chloro-2-((3,5-dichloro-N-ethylbenzamido)meth...)
Affinity DataEC50:  4.70E+5nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed