Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 2552
LigandChemical structure of BindingDB Monomer ID 21922BDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21899BDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21928BDBM21928(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[4...)
Affinity DataIC50: 16nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21930BDBM21930(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4...)
Affinity DataIC50: 16nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21915BDBM21915(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(py...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21920BDBM21920(2-[({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3...)
Affinity DataIC50: 18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21925BDBM21925(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21926BDBM21926(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-...)
Affinity DataIC50: 20nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21896BDBM21896(BMCL193485 Compound 2 | CHEMBL220037 | 4-[(3-chlor...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21897BDBM21897(4-[(3-chloro-4-fluorophenyl)amino]-8-fluoro-6-[(1H...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21898BDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21903BDBM21903(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21906BDBM21906(4-[(3-chloro-4-fluorophenyl)amino]-8-acetyl-6-[(1H...)
Affinity DataIC50: 23nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21929BDBM21929(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4...)
Affinity DataIC50: 25nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21933BDBM21933(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50: 30nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21896BDBM21896(BMCL193485 Compound 2 | CHEMBL220037 | 4-[(3-chlor...)
Affinity DataIC50: 30nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21938BDBM21938(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-...)
Affinity DataIC50: 41nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21939BDBM21939(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-...)
Affinity DataIC50: 43nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21931BDBM21931(methyl 5-[({8-bromo-4-[(3-chloro-4-fluorophenyl)am...)
Affinity DataIC50: 87nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21912BDBM21912(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50: 98nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21924BDBM21924(2-({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-...)
Affinity DataIC50: 110nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21927BDBM21927(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-({[4-...)
Affinity DataIC50: 130nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21932BDBM21932(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[({4...)
Affinity DataIC50: 130nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21902BDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21905BDBM21905(4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-[(1H-...)
Affinity DataIC50: 130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21909BDBM21909(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[2-...)
Affinity DataIC50: 130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21906BDBM21906(4-[(3-chloro-4-fluorophenyl)amino]-8-acetyl-6-[(1H...)
Affinity DataIC50: 156nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21900BDBM21900(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 160nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21918BDBM21918(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(6...)
Affinity DataIC50: 170nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21904BDBM21904(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 190nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21923BDBM21923(2-({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-...)
Affinity DataIC50: 200nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21935BDBM21935(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(2...)
Affinity DataIC50: 220nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21936BDBM21936(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1...)
Affinity DataIC50: 220nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21913BDBM21913(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50: 250nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21914BDBM21914(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({im...)
Affinity DataIC50: 280nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21911BDBM21911(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1...)
Affinity DataIC50: 290nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21934BDBM21934(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(2...)
Affinity DataIC50: 320nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21919BDBM21919(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[6...)
Affinity DataIC50: 350nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21917BDBM21917(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[({5...)
Affinity DataIC50: 500nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21897BDBM21897(4-[(3-chloro-4-fluorophenyl)amino]-8-fluoro-6-[(1H...)
Affinity DataIC50: 500nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21921BDBM21921(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2,3...)
Affinity DataIC50: 590nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21908BDBM21908(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50: 830nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21907BDBM21907(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50: 910nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21898BDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50: 1.80E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21902BDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 2.08E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21920BDBM21920(2-[({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3...)
Affinity DataIC50: 2.90E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21916BDBM21916(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[5...)
Affinity DataIC50: 3.00E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21899BDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50: 3.30E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 21910BDBM21910(N-{8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-3-cy...)
Affinity DataIC50: 5.00E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

LigandChemical structure of BindingDB Monomer ID 21903BDBM21903(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50: 5.00E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
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