Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50022167
LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  0.700nMpH: 5.5Assay Description:Blockade of pH 5.5-induced activation of TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  3nMAssay Description:Blockade of N-arachidonoyl-dopamine-induced activation of TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232113(1-(1H-indazol-4-yl)-3-(5-(trifluoromethyl)-2,3-dih...)
Affinity DataIC50:  3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20334(1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...)
Affinity DataIC50:  4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232111(1-(5-Cyclopropyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-...)
Affinity DataIC50:  4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232128(1-(1H-Indazol-4-yl)-3-(5-fluoro-4-morpholin-1-yl-i...)
Affinity DataIC50:  5nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232115(1-(4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-...)
Affinity DataIC50:  5nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232134(CHEMBL254867 | N-(5-tert-butyl-2,3-dihydro-1H-inde...)
Affinity DataIC50:  6nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232125(1-(1H-Indazol-4-yl)-3-[4-(4-trifluoromethyl)piperi...)
Affinity DataIC50:  7nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232137(1-(1H-indazol-4-yl)-3-(1-methyl-7-(trifluoromethyl...)
Affinity DataIC50:  7nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232140(CHEMBL255078 | N-(5-bromo-2,3-dihydro-1H-inden-1-y...)
Affinity DataIC50:  9nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232112(1-(5-tert-butyl-2,3-dihydro-1H-inden-2-yl)-3-(1H-i...)
Affinity DataIC50:  10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232126(1-(4-trifluoromethyl-2,3-dihydro-1H-inden-1-yl)-3-...)
Affinity DataIC50:  10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232123(CHEMBL428765 | N-(5-chloro-2,3-dihydro-1H-inden-1-...)
Affinity DataIC50:  10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232141(1-(1H-Indazol-4-yl)-3-(4-piperidin-1-yl-indan-1-yl...)
Affinity DataIC50:  10nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232127(1-(5-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50:  11nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232116(1-(1H-indazol-4-yl)-3-(7-(trifluoromethyl)-3,4-dih...)
Affinity DataIC50:  11nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232130(1-(4-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-i...)
Affinity DataIC50:  14nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232133(CHEMBL401128 | N-1H-indazol-4-yl-N'-(5-piperidin-1...)
Affinity DataIC50:  14nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232129(1-[5-(Cyano-isopropyl)-indan-1-yl]-3-(1H-indazol-4...)
Affinity DataIC50:  19nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232120(1-(1H-indazol-4-yl)-3-(4-(pyrrolidin-1-yl)-2,3-dih...)
Affinity DataIC50:  21nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20383(1-isoquinolin-5-yl-3-{1-[4-(trifluoromethyl)phenyl...)
Affinity DataIC50:  22nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232135((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-2-c...)
Affinity DataIC50:  34nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232117(1-(5-tert-butyl-2-fluoro-2,3-dihydro-1H-inden-1-yl...)
Affinity DataIC50:  35nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232119(1-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-3-(1H-inda...)
Affinity DataIC50:  40nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232132(1-(4-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50:  46nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232142(1-(1H-indazol-4-yl)-3-(1-(4-(trifluoromethyl)pheny...)
Affinity DataIC50:  47nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232136(CHEMBL428946 | N-(5-fluoro-2,3-dihydro-1H-inden-1-...)
Affinity DataIC50:  52nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232145(1-(1H-Indazol-4-yl)-3-(4-morpholin-1-yl-indan-1-yl...)
Affinity DataIC50:  65nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232121((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  97nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232143(CHEMBL398339 | N-[(1S)-5-tert-butyl-2,3-dihydro-1H...)
Affinity DataIC50:  123nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232118((R)-1-(5-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihyd...)
Affinity DataIC50:  127nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232138(1-(2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)u...)
Affinity DataIC50:  151nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232124(1-(5-tert-butyl-2,2-difluoro-2,3-dihydro-1H-inden-...)
Affinity DataIC50:  216nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232122(1-(7-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50:  595nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232139(1-(6,7-dihydro-5H-[1]pyridin-7-yl)-3-(1H-indazol-4...)
Affinity DataIC50:  1.35E+3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232144(1-(6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl)-3-(1H...)
Affinity DataIC50:  5.82E+3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232131(1-(6-methyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indaz...)
Affinity DataIC50:  7.20E+3nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed