Compile Data Set for Download or QSAR
maximum 50k data
Found 43 Enz. Inhib. hit(s) with all data for entry = 50026539
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251532(4-(carbamimidoyl)-N-(3,4-dimethoxyphenyl)-2-phenyl...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251606(CHEMBL479359 | N-(4-chlorophenyl)-4-[N'-cyano-N-(q...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251637(CHEMBL519095 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251638(CHEMBL480700 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251606(CHEMBL479359 | N-(4-chlorophenyl)-4-[N'-cyano-N-(q...)
Affinity DataIC50:  57nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251604(CHEMBL479358 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251680(4-[N'-cyano-N-(1,2,3,4-tetrahydroquinolin-5-yl)car...)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251607(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251607(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)
Affinity DataIC50:  93nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251717(CHEMBL520580 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)
Affinity DataIC50:  93nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251533(CHEMBL518308 | N-(4-chlorophenyl)-4-(N'-cyano-N-o-...)
Affinity DataIC50:  95nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251637(CHEMBL519095 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251715(CHEMBL481483 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251605(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251605(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251604(CHEMBL479358 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)
Affinity DataIC50:  125nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251638(CHEMBL480700 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251533(CHEMBL518308 | N-(4-chlorophenyl)-4-(N'-cyano-N-o-...)
Affinity DataIC50:  132nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50234969(CHEMBL402832 | N'-cyano-4-(2-(3,4-dimethoxyphenyl)...)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251717(CHEMBL520580 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)
Affinity DataIC50:  151nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251532(4-(carbamimidoyl)-N-(3,4-dimethoxyphenyl)-2-phenyl...)
Affinity DataIC50:  178nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251715(CHEMBL481483 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251639(4-[N'-cyano-N-(1H-indazol-4-yl)carbamimidoyl]-N-(3...)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251534(4-(carbamimidoyl)-N-(4-chlorophenyl)-N-methyl-2-ph...)
Affinity DataIC50:  290nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251564(4-(1-(o-toluidino)-2-nitrovinyl)-N-(4-chlorophenyl...)
Affinity DataIC50:  310nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251677(CHEMBL479577 | N-(4-chlorophenyl)-4-(N'-cyano-N-{2...)
Affinity DataIC50:  480nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251535(4-(4-chlorophenylsulfonyl)-N'-cyano-3-phenyl-N-o-t...)
Affinity DataIC50:  540nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251566(CHEMBL21149 | N1-(4-chlorophenyl)-2-phenyl-N4-o-to...)
Affinity DataIC50:  620nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50234969(CHEMBL402832 | N'-cyano-4-(2-(3,4-dimethoxyphenyl)...)
Affinity DataIC50:  630nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251566(CHEMBL21149 | N1-(4-chlorophenyl)-2-phenyl-N4-o-to...)
Affinity DataIC50:  780nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251534(4-(carbamimidoyl)-N-(4-chlorophenyl)-N-methyl-2-ph...)
Affinity DataIC50:  1.03E+3nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251677(CHEMBL479577 | N-(4-chlorophenyl)-4-(N'-cyano-N-{2...)
Affinity DataIC50:  1.07E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251679(CHEMBL481481 | N-(4-chlorophenyl)-4-[N'-cyano-N-(p...)
Affinity DataIC50:  1.33E+3nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251678(CHEMBL479578 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  1.66E+3nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251679(CHEMBL481481 | N-(4-chlorophenyl)-4-[N'-cyano-N-(p...)
Affinity DataIC50:  2.04E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251564(4-(1-(o-toluidino)-2-nitrovinyl)-N-(4-chlorophenyl...)
Affinity DataIC50:  3.11E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251535(4-(4-chlorophenylsulfonyl)-N'-cyano-3-phenyl-N-o-t...)
Affinity DataIC50:  4.06E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251678(CHEMBL479578 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)
Affinity DataIC50:  5.19E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251565(1-((4-((4-chlorophenyl)carbamoyl)-3-phenylpiperazi...)
Affinity DataIC50:  6.40E+3nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251563(4-(4-chlorobenzyl)-N'-cyano-3-phenyl-N-o-tolylpipe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251563(4-(4-chlorobenzyl)-N'-cyano-3-phenyl-N-o-tolylpipe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251565(1-((4-((4-chlorophenyl)carbamoyl)-3-phenylpiperazi...)
Affinity DataIC50:  1.03E+4nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251640(4-[N-(1-benzofuran-4-yl)-N'-cyanocarbamimidoyl]-N-...)
Affinity DataIC50:  2.49E+4nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed