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Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50027115
TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50035179(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.140nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263758(CHEMBL490188 | N-[2-(3-(3-Aminophenyl)-7-methoxyna...)
Affinity DataKi:  0.270nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50035179(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Affinity DataKi:  0.270nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263662(CHEMBL476341 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  0.280nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263659(CHEMBL476131 | N-[2-(3-(3-hydroxymethylphenyl)-7-m...)
Affinity DataKi:  0.360nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263602(CHEMBL453138 | N-[2-(3-phenyl-7-methoxynaphth-1-yl...)
Affinity DataKi:  0.370nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.410nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263713(CHEMBL491604 | N-[2-(3-(3-Formylphenyl)-7-methoxyn...)
Affinity DataKi:  0.420nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263551(CHEMBL477835 | N-[2-(3-(3-Methylaminophenyl)-7-met...)
Affinity DataKi:  0.510nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263661(CHEMBL518113 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  0.520nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263716(CHEMBL490595 | N-[2-(3-(3-Bromomethylphenyl)-7-met...)
Affinity DataKi:  0.560nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263714(3-[4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl]ben...)
Affinity DataKi:  0.640nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263549(CHEMBL477833 | N-[2-(3-(3-Iodomethylphenyl)-7-meth...)
Affinity DataKi:  0.710nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263600(CHEMBL478217 | N-[2-(3-(3-Dimethylaminophenyl)-7-m...)
Affinity DataKi:  0.940nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263712(CHEMBL491403 | N-[2-(3-(3-Methoxymethylphenyl)-7-m...)
Affinity DataKi:  0.950nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263603(CHEMBL517502 | N-[2-(3-(2-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  1.86nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263550(CHEMBL477834 | N-[2-(3-(3-Aminomethylphenyl)-7-met...)
Affinity DataKi:  3.40nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263603(CHEMBL517502 | N-[2-(3-(2-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  5.90nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263759(CHEMBL489170 | N-[2-(3-(3-Acetylaminophenyl)-7-met...)
Affinity DataKi:  7.54nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263601(CHEMBL478218 | N-[2-(3-(3-Ethoxycarbonylaminopheny...)
Affinity DataKi:  8.30nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263660(CHEMBL476132 | N-[2-(3-(4-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  23nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263714(3-[4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl]ben...)
Affinity DataKi:  24.7nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263759(CHEMBL489170 | N-[2-(3-(3-Acetylaminophenyl)-7-met...)
Affinity DataKi:  38.4nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263715(3-(4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl)ben...)
Affinity DataKi:  43.3nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263663(CHEMBL478438 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  48.3nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263600(CHEMBL478217 | N-[2-(3-(3-Dimethylaminophenyl)-7-m...)
Affinity DataKi:  49.8nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263716(CHEMBL490595 | N-[2-(3-(3-Bromomethylphenyl)-7-met...)
Affinity DataKi:  50.7nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263602(CHEMBL453138 | N-[2-(3-phenyl-7-methoxynaphth-1-yl...)
Affinity DataKi:  53nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263662(CHEMBL476341 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  60.3nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263758(CHEMBL490188 | N-[2-(3-(3-Aminophenyl)-7-methoxyna...)
Affinity DataKi:  82nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263551(CHEMBL477835 | N-[2-(3-(3-Methylaminophenyl)-7-met...)
Affinity DataKi:  82.5nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263601(CHEMBL478218 | N-[2-(3-(3-Ethoxycarbonylaminopheny...)
Affinity DataKi:  124nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263661(CHEMBL518113 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  125nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263549(CHEMBL477833 | N-[2-(3-(3-Iodomethylphenyl)-7-meth...)
Affinity DataKi:  126nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263713(CHEMBL491604 | N-[2-(3-(3-Formylphenyl)-7-methoxyn...)
Affinity DataKi:  137nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263712(CHEMBL491403 | N-[2-(3-(3-Methoxymethylphenyl)-7-m...)
Affinity DataKi:  204nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263659(CHEMBL476131 | N-[2-(3-(3-hydroxymethylphenyl)-7-m...)
Affinity DataKi:  275nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263660(CHEMBL476132 | N-[2-(3-(4-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  297nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263550(CHEMBL477834 | N-[2-(3-(3-Aminomethylphenyl)-7-met...)
Affinity DataKi:  1.39E+3nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263663(CHEMBL478438 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataKi:  1.51E+3nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263715(3-(4-(2-Acetylaminoethyl)-6-methoxynaphth-2-yl)ben...)
Affinity DataKi:  3.83E+3nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263758(CHEMBL490188 | N-[2-(3-(3-Aminophenyl)-7-methoxyna...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263551(CHEMBL477835 | N-[2-(3-(3-Methylaminophenyl)-7-met...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263716(CHEMBL490595 | N-[2-(3-(3-Bromomethylphenyl)-7-met...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263662(CHEMBL476341 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263661(CHEMBL518113 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263713(CHEMBL491604 | N-[2-(3-(3-Formylphenyl)-7-methoxyn...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50035179(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMelatonin receptor type 1B(Human)
University of Lille 2

Curated by ChEMBL
LigandPNGBDBM50263602(CHEMBL453138 | N-[2-(3-phenyl-7-methoxynaphth-1-yl...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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