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Found 69 Enz. Inhib. hit(s) with all data for entry = 50028591
LigandPNGBDBM50259015(5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259015(5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...)
Affinity DataIC50:  38nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259015(5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...)
Affinity DataIC50:  54nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50:  370nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259016(3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyra...)
Affinity DataIC50:  520nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259058(3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benz...)
Affinity DataIC50:  790nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259058(3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benz...)
Affinity DataIC50:  970nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE8aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE8bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4dMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE3bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE3aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259057(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259017(5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259017(5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50:  1.43E+3nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259108((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259059(3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259016(3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyra...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259017(5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259016(3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyra...)
Affinity DataIC50:  2.65E+3nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259105(CHEMBL466680 | N-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259057(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259106(1-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-py...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259108((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259057(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Affinity DataIC50:  4.95E+3nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259057(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259107(3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259108((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259058(3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benz...)
Affinity DataIC50:  7.81E+3nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259108((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259059(3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259107(3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259106(1-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-py...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259105(CHEMBL466680 | N-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259060(CHEMBL466475 | N-[(1R,2S)2-(3-Isopropyl-7-oxo-6,7-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259059(3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259060(CHEMBL466475 | N-[(1R,2S)2-(3-Isopropyl-7-oxo-6,7-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259105(CHEMBL466680 | N-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259106(1-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-py...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259107(3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259060(CHEMBL466475 | N-[(1R,2S)2-(3-Isopropyl-7-oxo-6,7-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259057(3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE3aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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