Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50030305
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001285BDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataKi:  600nMAssay Description:Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294038BDBM50294038(LY-329146 | N-(4-{3-[4-(2-hexahydro-1-pyridinyleth...)
Affinity DataIC50: 800nMAssay Description:Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294036BDBM50294036(2-(3,3-Diethylthioureido)benzo[b]thiophene-3-carbo...)
Affinity DataIC50: 932nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084979BDBM50084979(Dehydrosilylbin | 3,5,7-Trihydroxy-2-[3-(4-hydroxy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294037BDBM50294037(2-(3-Cyclohexyl-3-methylthioureido)benzo[b]thiophe...)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111915BDBM50111915(LY-402913 | 2-[3-(9-Chloro-3-methyl-4-oxo-4H-isoxa...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294032BDBM50294032(2-(3,3-Diethylthioureido)-5,6-dihydro-4H-cyclopent...)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294033BDBM50294033(2-(3,3-Diethylthioureido)-4,5,6,7-tetrahydrobenzo[...)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001285BDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant MRP1 expressed in human HeLa T5 cells assessed as ATP-dependent transport of [3H]para-aminohippurateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294034BDBM50294034((R,S)-2-(3,3-Diethylthioureido)-4-methyl-4,5,6,7-t...)
Affinity DataIC50: 4.06E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294041BDBM50294041(3-(3,3-Diethylthioureido)thiophene-2-carboxylic Ac...)
Affinity DataIC50: 4.18E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294048BDBM50294048(2-(3-Cyclohexyl-3-methylthioureido)-4,5-dimethylth...)
Affinity DataIC50: 4.19E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294042BDBM50294042(2-(3,3-Diethylthioureido)thiophene-3-carboxylic Ac...)
Affinity DataIC50: 4.46E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294043BDBM50294043(2-(3-Cyclohexyl-3-methylthioureido)thiophene-3-car...)
Affinity DataIC50: 4.51E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294055BDBM50294055(3-(3,3-Diethylureido)-2-naphthoic Acid | CHEMBL552...)
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294035BDBM50294035(2-(3,3-Diethylthioureido)-5,6,7,8-tetrahydro-4H-cy...)
Affinity DataIC50: 5.97E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50294036BDBM50294036(2-(3,3-Diethylthioureido)benzo[b]thiophene-3-carbo...)
Affinity DataIC50: 6.16E+3nMAssay Description:Inhibition of BCRP expressed in MCF7 MX cells by Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294040BDBM50294040(2-(3,3-Diethylureido)-4,5,6,7-tetrahydrobenzo[b]th...)
Affinity DataIC50: 8.29E+3nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50294034BDBM50294034((R,S)-2-(3,3-Diethylthioureido)-4-methyl-4,5,6,7-t...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of BCRP expressed in MCF7 MX cells by Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50294043BDBM50294043(2-(3-Cyclohexyl-3-methylthioureido)thiophene-3-car...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of BCRP expressed in MCF7 MX cells by Hoechst 33342 stainingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294039BDBM50294039(2-(3,3-Diethylureido)-5,6-dihydro-4H-cyclopenta[b]...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294050BDBM50294050(2-(3-Cyclohexyl-3-methylureido)benzoic Acid | CHEM...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294045BDBM50294045(2-(3,3-Diethylthioureido)-5-phenylthiophene-3-carb...)
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294044BDBM50294044(2-(3,3-Diethylthioureido)-4-isopropylthiophene-3-c...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294057BDBM50294057(2-(3-Cyclohexyl-3-methylthioureido)benzoic Acid | ...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294030BDBM50294030(4,5-Dimethyl-2-[(4-morpholinylthiocarbonyl)amino]t...)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294061BDBM50294061(2-[(1-Pyrrolidinylthiocarbonyl)amino]benzoic Acid ...)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294047BDBM50294047(2-(3,3-Diethylthioureido)-4,5-dimethylthiophene-3-...)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294062BDBM50294062(2-[(1-Piperidinylthiocarbonyl)amino]benzoic Acid |...)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294056BDBM50294056(2-(3,3-Diethylthioureido)benzoic Acid | CHEMBL5696...)
Affinity DataIC50: 2.16E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294053BDBM50294053(2-(3-Cyclohexyl-3-methylureido)-5-methylbenzoic Ac...)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294060BDBM50294060(2-[3-Methyl-3-(2-phenylethyl)thioureido]benzoic Ac...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294049BDBM50294049(2-(3,3-diethylureido)benzoic acid | CHEMBL558351)
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294046BDBM50294046(2-[(4-Morpholinylthiocarbonyl)amino]-5-phenylthiop...)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294059BDBM50294059(2-(3-Benzyl-3-methylthioureido)benzoic Acid | CHEM...)
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294051BDBM50294051(2-(3-Benzyl-3-methylureido)benzoic Acid | CHEMBL55...)
Affinity DataIC50: 4.26E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294052BDBM50294052(2-[(1-Pyrrolidinylcarbonyl)amino]benzoic Acid | CH...)
Affinity DataIC50: 4.31E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294054BDBM50294054(4,5-Dimethyl-2-[(4-morpholinylcarbonyl)amino]benzo...)
Affinity DataIC50: 4.34E+4nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294031BDBM50294031(5-Carbamoyl-2-(3,3-diethylthioureido)-4-methylthio...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294058BDBM50294058(2-(3-Methyl-3-phenylthioureido)benzoic Acid | CHEM...)
Affinity DataIC50: 1.98E+5nMAssay Description:Inhibition of MRP1 expressed in multidrug resistant human 2008 cells assessed as calcein AM accumulation by fluorescence assay in presence of p-gp an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed