Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50022599
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 40nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S/A2016T mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 40nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14047(N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H...)
Affinity DataIC50: 62nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14055(N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 63nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 104nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 244nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50653001(CHEMBL5712056)
Affinity DataIC50: 290nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 700nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM86728(1-(5-isoquinolinesulfonyl)-homopiperazine.HCl | CA...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50417686(CHEMBL1233300)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14047(N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14028(H-1152 | 4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S/A2016T mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14047(N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50417686(CHEMBL1233300)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50653001(CHEMBL5712056)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50653001(CHEMBL5712056)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50319631(trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexa...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S/A2016T mutant (1326 to 2527 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM86728(1-(5-isoquinolinesulfonyl)-homopiperazine.HCl | CA...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50417686(CHEMBL1233300)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM86728(1-(5-isoquinolinesulfonyl)-homopiperazine.HCl | CA...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14055(N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14055(N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed