Compile Data Set for Download or QSAR
Report error Found 94 Enz. Inhib. hit(s) with all data for entry = 50031060
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306267BDBM50306267(1-(2-(4-phenylpiperidin-1-yl)acetyl)-2,3,9,9a-tetr...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306256BDBM50306256(1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306262BDBM50306262(1-(pyrrolidine-3-carbonyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306253BDBM50306253(1-(2-(pyridin-3-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306253BDBM50306253(1-(2-(pyridin-3-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306257BDBM50306257(1-(3-(1H-benzo[d]imidazol-1-yl)propanoyl)-2,3,9,9a...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306263BDBM50306263(1-(azetidine-3-carbonyl)-2,3,9,9a-tetrahydro-1H-be...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306260BDBM50306260(1-((S)-pyrrolidine-2-carbonyl)-2,3,9,9a-tetrahydro...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306271BDBM50306271(1-benzoyl-2,3,9,9a-tetrahydro-1H-benzo[de][1,7]nap...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306273BDBM50306273(1-(3-phenylpropanoyl)-2,3,9,9a-tetrahydro-1H-benzo...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306243BDBM50306243(1-(2-(3-chlorophenyl)acetyl)-2,3,9,9a-tetrahydro-1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306242BDBM50306242(1-(2-(4-chlorophenyl)acetyl)-2,3,9,9a-tetrahydro-1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306246BDBM50306246(1-(2-(3-methoxyphenyl)acetyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306256BDBM50306256(1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306245BDBM50306245(1-(2-(4-methoxyphenyl)acetyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306264BDBM50306264(1-(2-(piperidin-1-yl)acetyl)-2,3,9,9a-tetrahydro-1...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306254BDBM50306254(1-(2-(4-methylthiazol-2-yl)acetyl)-2,3,9,9a-tetrah...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306279BDBM50306279(1-(4-chlorobenzoyl)-2,3,9,9a-tetrahydro-1H-benzo[d...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306248BDBM50306248(1-(2-(4-bromophenyl)acetyl)-2,3,9,9a-tetrahydro-1H...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306272BDBM50306272(1-(2-phenylacetyl)-2,3,9,9a-tetrahydro-1H-benzo[de...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306276BDBM50306276(phenyl 7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de][1...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306268BDBM50306268(N,N-dimethyl-4-oxo-4-(7-oxo-2,3,7,8,9,9a-hexahydro...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306250BDBM50306250(4-(2-oxo-2-(7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306252BDBM50306252(1-(2-(pyridin-4-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306259BDBM50306259(1-(cyclopentanecarbonyl)-2,3,9,9a-tetrahydro-1H-be...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306266BDBM50306266(1-(2-(4-phenylpiperazin-1-yl)acetyl)-2,3,9,9a-tetr...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306274BDBM50306274(7-oxo-N-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzo[de]...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306275BDBM50306275(N-benzyl-7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de]...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306241BDBM50306241(1-(4-((diethylamino)methyl)benzoyl)-2,3,9,9a-tetra...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306255BDBM50306255(1-(2-(3-methylbenzo[b]thiophen-2-yl)acetyl)-2,3,9,...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306251BDBM50306251(1-(2-(pyridin-2-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306258BDBM50306258(1-(3-(1-methyl-1H-pyrazol-4-yl)propanoyl)-2,3,9,9a...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306261BDBM50306261(1-((2S)-1-(1-hydroxyethyl)pyrrolidine-2-carbonyl)-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306277BDBM50306277(benzyl 7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de][1...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306269BDBM50306269(5-oxo-5-(7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de]...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306244BDBM50306244(1-(2-(2-chlorophenyl)acetyl)-2,3,9,9a-tetrahydro-1...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306249BDBM50306249(1-(2-(4-(benzyloxy)phenyl)acetyl)-2,3,9,9a-tetrahy...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306247BDBM50306247(1-(2-(2-methoxyphenyl)acetyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306281BDBM50306281(1-(2-chlorobenzoyl)-2,3,9,9a-tetrahydro-1H-benzo[d...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306280BDBM50306280(1-(3-chlorobenzoyl)-2,3,9,9a-tetrahydro-1H-benzo[d...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306283BDBM50306283(1-(3-(1,4-diazepane-1-carbonyl)benzoyl)-2,3,9,9a-t...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306253BDBM50306253(1-(2-(pyridin-3-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306256BDBM50306256(1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306278BDBM50306278(1-(benzylsulfonyl)-2,3,9,9a-tetrahydro-1H-benzo[de...)
Affinity DataIC50: 83nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306265BDBM50306265(1-(2-(4-methylpiperazin-1-yl)acetyl)-2,3,9,9a-tetr...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306282BDBM50306282(1-(4-(1,4-diazepane-1-carbonyl)benzoyl)-2,3,9,9a-t...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306277BDBM50306277(benzyl 7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de][1...)
Affinity DataEC50:  130nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306286BDBM50306286(1,2,3,8,9,9a-hexahydro-7H-benzo[de]-1,7-naphthyrid...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306245BDBM50306245(1-(2-(4-methoxyphenyl)acetyl)-2,3,9,9a-tetrahydro-...)
Affinity DataEC50:  160nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306260BDBM50306260(1-((S)-pyrrolidine-2-carbonyl)-2,3,9,9a-tetrahydro...)
Affinity DataEC50:  180nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
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