Compile Data Set for Download or QSAR
Report error Found 56 Enz. Inhib. hit(s) with all data for entry = 3559
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.29nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Vanderbilt University

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.14nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 25.1nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50: 26.7nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 40.7nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 42.8nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataEC50:  100nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36354(DMH1 | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 108nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 148nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM5410(4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phe...)
Affinity DataIC50: 161nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36354(DMH1 | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyr...)
Affinity DataEC50:  200nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 215nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 235nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 565nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50: 998nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataEC50:  1.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataEC50:  1.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5410(4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phe...)
Affinity DataEC50:  1.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.12E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 1.58E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50: 1.94E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM4810(cid_5329098 | CHEMBL276711 | SU5146 | (3Z)-3-[(3,5...)
Affinity DataEC50:  2.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36353(dorsomorphin (91E))
Affinity DataEC50:  2.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36353(dorsomorphin (91E))
Affinity DataEC50:  2.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM36356(DMH3 | N,N-dimethyl-3-(4- (3-(quinolin-4-yl)pyrazo...)
Affinity DataIC50: 2.06E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 2.42E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataEC50:  2.50E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataEC50:  3.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataIC50: 3.53E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM5410(4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phe...)
Affinity DataIC50: 3.56E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.53E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36353(dorsomorphin (91E))
Affinity DataEC50:  5.00E+3nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataEC50:  5.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataEC50:  5.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM4810(cid_5329098 | CHEMBL276711 | SU5146 | (3Z)-3-[(3,5...)
Affinity DataEC50:  5.00E+3nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36352(dorsomorphin (6LE))
Affinity DataEC50:  5.00E+3nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
LigandPNGBDBM5410(4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phe...)
Affinity DataIC50: 8.04E+3nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.06E+4nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Vanderbilt University

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataIC50: 1.08E+4nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5416(CHEMBL324153 | 4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1...)
Affinity DataEC50:  2.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataEC50:  2.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36355(DMH2 | 4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]py...)
Affinity DataEC50:  2.50E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5294(dorsomorphin (6LP) | 6-(4-methoxyphenyl)-3-phenylp...)
Affinity DataEC50: >5.00E+4nMAssay Description:The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36352(dorsomorphin (6LE))
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM5294(dorsomorphin (6LP) | 6-(4-methoxyphenyl)-3-phenylp...)
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36354(DMH1 | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyr...)
Affinity DataEC50: >5.00E+4nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
TargetReceptor protein serine/threonine kinase(Zebrafish)
Vanderbilt University

LigandPNGBDBM36352(dorsomorphin (6LE))
Affinity DataEC50:  5.00E+4nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2011
Entry Details Article
PubMed
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