Compile Data Set for Download or QSAR
maximum 50k data
Found 30 Enz. Inhib. hit(s) with all data for entry = 50031427
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313095(4-chloro-3-(1-(2-chlorophenyl)-1H-pyrazolo[4,3-d]p...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313114(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313116(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313106(CHEMBL1081991 | N-cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313105(4-chloro-N-cyclopropyl-3-(1-(2,5-difluorophenyl)-1...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313110(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313112(CHEMBL1080673 | N-cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313100(CHEMBL1088443 | N-cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313108(CHEMBL1082159 | N-cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313102(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313109(CHEMBL1082182 | N-cyclopropyl-3-(1-(4-fluorophenyl...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313096(CHEMBL1087386 | N-cyclopropyl-3-(1-(3-fluorophenyl...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313097(4-chloro-N-cyclopropyl-3-(1-(3-fluorophenyl)-1H-py...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313115(CHEMBL1081037 | N-cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313111(CHEMBL1082183 | N-cyclopropyl-3-(1-(4-fluorophenyl...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313098(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-1H-py...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313113(CHEMBL1082205 | N-cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313103(CHEMBL1088166 | N-cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313099(3-(1-(2,4-difluorophenyl)-1H-pyrazolo[4,3-d]pyrida...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313104(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313101(CHEMBL1088031 | N-cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed