Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50004458
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483163(CHEMBL1630067)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483151(CHEMBL1630068)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483149(CHEMBL1630065)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483150(CHEMBL1630066)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483155(CHEMBL1630076)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Mouse)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483144(GSK2210875 | CHEMBL1630057)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Mouse)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483145(CHEMBL1630080)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483145(CHEMBL1630080)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483152(CHEMBL1630069)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483153(CHEMBL1630070)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483147(CHEMBL1630061)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483144(GSK2210875 | CHEMBL1630057)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483160(CHEMBL1630064)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483146(CHEMBL1630059)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483157(CHEMBL1630079)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483158(CHEMBL1630077)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483156(CHEMBL1630078)
Affinity DataIC50: 316nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483166(CHEMBL1630060)
Affinity DataIC50: 501nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483168(CHEMBL1630062)
Affinity DataIC50: 2.51E+3nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483162(CHEMBL1630058)
Affinity DataIC50: 3.16E+3nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483148(CHEMBL1630063)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483164(CHEMBL1630071)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483161(CHEMBL1630075)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483167(CHEMBL1630073)
Affinity DataIC50: 3.16E+4nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483154(CHEMBL1630072)
Affinity DataIC50: 3.16E+4nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483165(CHEMBL1630074)
Affinity DataIC50: 3.16E+4nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483144(GSK2210875 | CHEMBL1630057)
Affinity DataIC50: 3.16E+4nMAssay Description:Antagonist activity at mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483159(CHEMBL1630081)
Affinity DataIC50: 3.16E+4nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483145(CHEMBL1630080)
Affinity DataIC50: 5.01E+4nMAssay Description:Antagonist activity at mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed