Compile Data Set for Download or QSAR
maximum 50k data
Found 56 Enz. Inhib. hit(s) with all data for entry = 50040364
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  560nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  924nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  2.21E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393111(CHEMBL2153261)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  3.36E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  4.76E+3nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215927(4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...)
Affinity DataIC50:  8.03E+3nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393113(CHEMBL2153265)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Sus scrofa)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393115(CHEMBL575945)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393111(CHEMBL2153261)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393110(CHEMBL2153260)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393110(CHEMBL2153260)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393115(CHEMBL575945)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393114(CHEMBL2153267)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393114(CHEMBL2153267)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393111(CHEMBL2153261)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393115(CHEMBL575945)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Sus scrofa)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215927(4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393113(CHEMBL2153265)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393110(CHEMBL2153260)
Affinity DataIC50:  6.19E+4nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215927(4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393111(CHEMBL2153261)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  8.78E+4nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  530nMAssay Description:Binding affinity to C-terminal kinase domain 2 of RPS6KA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataKd:  290nMAssay Description:Binding affinity to JH domain of TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  2.40E+4nMAssay Description:Binding affinity to ULK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 32B(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to YANK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  220nMAssay Description:Binding affinity to YSK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase-like 5(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to CDKL5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  7.50E+3nMAssay Description:Binding affinity to CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to CAMKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit gamma(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to CAMK2GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataKd:  720nMAssay Description:Binding affinity to BMPR1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to AAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to CLK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to CAMKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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