Compile Data Set for Download or QSAR
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Found 135 Enz. Inhib. hit(s) with all data for entry = 50033363
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataIC50:  23nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343920(4-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343916(1-(2-(4-(4-Chlorophenoxy)phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343915(1-(2-(4-(4-Fluorophenoxy)phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343918(2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343917(1-(2-(4-(4-Bromophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343904(2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyridine |...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343912(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343917(1-(2-(4-(4-Bromophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343920(4-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343927(1-(2-(4-(4-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343914(1-(2-(4-(4-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343913(1-(2-(4-(3-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  540nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343905(4-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyridine |...)
Affinity DataIC50:  580nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343918(2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  630nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343905(4-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyridine |...)
Affinity DataIC50:  670nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343925(1-(2-(4-(2-Nitrophenoxy)-phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  680nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343919(3-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343927(1-(2-(4-(4-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343916(1-(2-(4-(4-Chlorophenoxy)phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  730nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343912(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  730nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343904(2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyridine |...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50085245(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Affinity DataIC50:  780nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343919(3-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  970nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343915(1-(2-(4-(4-Fluorophenoxy)phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  990nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343920(4-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343914(1-(2-(4-(4-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343923(CHEMBL1775110 | N-(4-(4-(2-(Pyrrolidin-1-yl)ethoxy...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343923(CHEMBL1775110 | N-(4-(4-(2-(Pyrrolidin-1-yl)ethoxy...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343910(2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyrazine |...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343912(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343917(1-(2-(4-(4-Bromophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343925(1-(2-(4-(2-Nitrophenoxy)-phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343925(1-(2-(4-(2-Nitrophenoxy)-phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343925(1-(2-(4-(2-Nitrophenoxy)-phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343927(1-(2-(4-(4-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343916(1-(2-(4-(4-Chlorophenoxy)phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataIC50:  3.22E+4nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343911(3-Nitro-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)py...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343904(2-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)pyridine |...)
Affinity DataIC50:  3.44E+4nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343927(1-(2-(4-(4-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50:  3.53E+4nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343920(4-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenoxy)aniline | ...)
Affinity DataIC50:  3.63E+4nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343912(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Affinity DataIC50:  4.14E+4nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50343925(1-(2-(4-(2-Nitrophenoxy)-phenoxy)ethyl)pyrrolidine...)
Affinity DataIC50:  6.10E+4nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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