Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50022556
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EGFR (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ErbB4 (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 3nMAssay Description:Inhibition of ErbB2 (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM32368(LAPATINIB)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKT1 (104 to end residues) catalytic domain expressed in baculovirus infected sf21 insect cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length PIM2 expressed in baculovirus infected sf21 insect cells using poly(Glu-Tyr) at 4:1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human JAK2 (826 to end residues) catalytic domain expressed in baculovirus infected sf21 insect cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human p70S6K1 (1 to 421 residues) catalytic domain expressed in baculovirus infected sf21 insect cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length GSK3b expressed in baculovirus infected sf21 insect cells using poly(Glu-Tyr) at 4:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length CDK2 expressed in baculovirus infected sf21 insect cells using poly(Glu-Tyr) at 4:1 ratio as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length AURA expressed in baculovirus infected sf21 insect cells using poly(Glu-Tyr) at 4:1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDR (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Flt-1 (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Kit (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Met (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Src (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA2 (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Abl (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RON (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C beta type(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length PKCb2 expressed in baculovirus infected sf21 insect cells using poly(Glu-Tyr) at 4:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length SYK expressed in baculovirus infected sf21 insect cells using poly(Glu-Tyr) at 4:1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human Tie2 (771 to end residues) cytoplasmic domain expressed in baculovirus infected sf21 insect cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50652893(Allitinib | Als 1306 | Ast 1306 | Ast-1306 | Ast13...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphB2 (unknown origin) expressed in Bac-to-Bac baculovirus expression system using poly(Glu-Tyr) at 4:1 ratio as substrate in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed