Report error Found 143 Enz. Inhib. hit(s) with all data for entry = 50034012
TargetFibroblast growth factor receptor 3(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FGFR3 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant FGFR1More data for this Ligand-Target Pair
3D Structure (crystal)TargetFibroblast growth factor receptor 3(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant FGFR3More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant FGFR2More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of FGFR3-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of FGFR2 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of FGFR1-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of wild type FGFR1 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of wild type FGFR2 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant FGFR4More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP3A4 using DBF as substrateMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 168nMAssay Description:Inhibition of wild type FGFR4 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant VEGFR2More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C19 using CEC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant LYN kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP3A4 using BFC as substrateMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant KIT kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP2C19 using CEC as substrateMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 938nMAssay Description:Inhibition of VEGFR2 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 using BFC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP3A4 using BFC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP2C19 using CEC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant YES kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP3A4 using BFC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C19 using CEC as substrateMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of VEGFR2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of VEGFR1 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP2C9 using MFC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant FYN kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.05E+3nMAssay Description:Inhibition of TIE2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of VEGFR3 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant ABL kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant LCK kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP3A4 using DBF as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP3A4 using DBF as substrateMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of KIT juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of PDGFRalpha-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of JAK2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of RON-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of SRC-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of MET-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of LYN-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
Affinity DataIC50: 3.04E+3nMAssay Description:Inhibition of EPHB1-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of ALK juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of TRKB juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of FLT3-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of ROS-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of TYK2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of recombinant RETMore data for this Ligand-Target Pair
