Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50046836
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133864BDBM50133864(CHEMBL2139947 | US10251893, Compound 59)
Affinity DataIC50: 0.0740nMAssay Description:Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133870BDBM50133870(CHEMBL3188386 | CHEBI:78030 | US10251893, Compound...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133865BDBM50133865(CHEMBL3633801)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133866BDBM50133866(CHEMBL3633802)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133868BDBM50133868(CHEMBL3633804)
Affinity DataIC50: 5nMAssay Description:Inhibition of porcupine in human HEK293 cells by STF reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133866BDBM50133866(CHEMBL3633802)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse porcupine expressed in human HT1080 cells assessed as reduction in beta catenin reporter activity using firefly luciferase substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133869BDBM50133869(CHEMBL3633800)
Affinity DataIC50: 27nMAssay Description:Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50428029BDBM50428029(CHEMBL1257063)
Affinity DataIC50: 60nMAssay Description:Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133867BDBM50133867(CHEMBL3633803)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2016
Entry Details Article
PubMed