Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50047641
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of aromatase (unknown origin) transfected in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50123026(CHEMBL3623232)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of aromatase in human JEG3 cells using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 1 hr by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180685(CHEMBL3818343)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of aromatase in human JEG3 cells using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 1 hr by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50014315((rac)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)me...)
Affinity DataIC50: 1.40nMAssay Description:Reversible inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM10015(NSC719344 | arimidex | 2-[3-(1-cyano-1-methylethyl...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of aromatase (unknown origin) transfected in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50240798(CHEMBL132530 | 4-hyroxyandrostenedione | (8R,9S,10...)
Affinity DataIC50: 30nMAssay Description:Inhibition of particulate fractions of human breast cancer derived aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50435004(CHEMBL2386284)
Affinity DataIC50: 30nMAssay Description:Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180683(CHEMBL3818720)
Affinity DataKi:  84nMAssay Description:Competitive inhibition of human placental microsomal aromatase using androgen as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180688(CHEMBL3818725)
Affinity DataIC50: 168nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50123012(CHEMBL3623217)
Affinity DataIC50: 169nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 5 mins by be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180689(CHEMBL3819184)
Affinity DataIC50: 180nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180690(CHEMBL3819549)
Affinity DataIC50: 450nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50123151(CHEMBL3623223)
Affinity DataIC50: 470nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180687(CHEMBL3818442)
Affinity DataIC50: 512nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180692(CHEMBL3818728)
Affinity DataIC50: 590nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180691(CHEMBL3818338)
Affinity DataIC50: 750nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180686(CHEMBL3818279)
Affinity DataIC50: 800nMAssay Description:Inhibition of human aromatase using testosterone as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50123013(CHEMBL3623216)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50435003(ENDOXIFEN)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM9460(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | C...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human aromatase transfected in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50: 5.30E+5nMAssay Description:Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed