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Found 8 Enz. Inhib. hit(s) with all data for entry = 50048117
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM80861(4-[2-(2-Cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrim...)
Affinity DataIC50:  316nMAssay Description:Inhibition of wild type recombinant Atg4B (unknown origin) expressed in Escherichia coli BL21 DE3 using N-terminal His6-tagged LC3B-PLA2 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50085339(((S)-1-Benzyl-3-chloro-2-oxo-propyl)-carbamic acid...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Atg4B (unknown origin) using YFP-LC3B-EmGFP as substrate after 40 mins by FRET-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of Atg4B (unknown origin) using YFP-LC3B-EmGFP as substrate after 40 mins by FRET-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM33413(benzo[7]annulene-8-carboxylic acid, 5)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of wild type recombinant Atg4B (unknown origin) expressed in Escherichia coli BL21 DE3 using N-terminal His6-tagged LC3B-PLA2 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM4078(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of wild type recombinant Atg4B (unknown origin) expressed in Escherichia coli BL21 DE3 using N-terminal His6-tagged LC3B-PLA2 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of human recombinant GST-tagged Atg4B expressed in Escherichia coli using LC3B-GST as substrate after 6 mins by SDS-PAGE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-(2-pyridinyl)-2-pyridinecarbothio...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of Atg4B (unknown origin) using LC3B-GST as substrate preincubated for 24 hrs followed by substrate addition measured for 3 mins by SDS-PA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50060874(1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[...)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of Atg4B (unknown origin) using YFP-LC3B-EmGFP as substrate after 40 mins by FRET-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed