Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50000315
LigandChemical structure of BindingDB Monomer ID 50195475BDBM50195475(CHEMBL3393127)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246158BDBM50246158(CHEMBL3393128)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246156BDBM50246156(CHEMBL4104303)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 1 alpha1/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246171BDBM50246171(CHEMBL4066628)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246157BDBM50246157(CHEMBL4071175)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 3 alpha1/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 2 alpha1/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 8 alpha2/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 11 alpha2/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 9 alpha2/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246153BDBM50246153(CHEMBL4071158)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246155BDBM50246155(CHEMBL4078549)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit beta-2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 12 alpha2/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit gamma-1(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 10 alpha2/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 4 alpha1/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246154BDBM50246154(CHEMBL4091973)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase subunit gamma-2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  118nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 5 alpha1/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246161BDBM50246161(CHEMBL4088692)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246143BDBM50246143(CHEMBL4071467)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246144BDBM50246144(CHEMBL4066650)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetTranscription factor Dp-2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataIC50: 1.80E+3nMAssay Description:Binding affinity to DP2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246125BDBM50246125(CHEMBL4078587)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50:  2.86E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 6 alpha1/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246124BDBM50246124(CHEMBL4097407)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246159BDBM50246159(CHEMBL4090039)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246133BDBM50246133(CHEMBL4064094)
Affinity DataEC50:  6.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246142BDBM50246142(CHEMBL4071905)
Affinity DataEC50:  7.40E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246141BDBM50246141(CHEMBL4093406)
Affinity DataEC50:  8.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246123BDBM50246123(CHEMBL4066431)
Affinity DataEC50:  8.10E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246126BDBM50246126(CHEMBL4077813)
Affinity DataEC50:  8.50E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PRAK expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of human PXR transfected in human hepatoma cells assessed as induction of CYP3A4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50246160BDBM50246160(CHEMBL4061943)
Affinity DataEC50:  3.60E+4nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetTranscription factor Dp-2(Human)
Metabasis Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246120BDBM50246120(CHEMBL4082745)
Affinity DataIC50: 8.60E+4nMAssay Description:Binding affinity to DP2 receptor (unknown origin) in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed