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Found 32 Enz. Inhib. hit(s) with all data for entry = 50001457
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399971(US10323042, Example 51 | US10738063, Example 51)
Affinity DataIC50:  12nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399964(US10323042, Example 44 | US10738063, Example 44)
Affinity DataIC50:  21nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399971(US10323042, Example 51 | US10738063, Example 51)
Affinity DataIC50:  27nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399923(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-6,7-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  31nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399923(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-6,7-...)
Affinity DataIC50:  32nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399952(US10323042, Example 32 | US10738063, Example 32)
Affinity DataIC50:  48nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399964(US10323042, Example 44 | US10738063, Example 44)
Affinity DataIC50:  56nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399923(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-6,7-...)
Affinity DataIC50:  104nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399971(US10323042, Example 51 | US10738063, Example 51)
Affinity DataIC50:  108nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399947(US10323042, Example 27 | US10738063, Example 27)
Affinity DataIC50:  115nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399964(US10323042, Example 44 | US10738063, Example 44)
Affinity DataIC50:  160nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399947(US10323042, Example 27 | US10738063, Example 27)
Affinity DataIC50:  178nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399952(US10323042, Example 32 | US10738063, Example 32)
Affinity DataIC50:  188nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399952(US10323042, Example 32 | US10738063, Example 32)
Affinity DataIC50:  207nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399921(Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-6,7-dihy...)
Affinity DataIC50:  211nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399921(Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-6,7-dihy...)
Affinity DataIC50:  241nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  306nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399947(US10323042, Example 27 | US10738063, Example 27)
Affinity DataIC50:  389nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399971(US10323042, Example 51 | US10738063, Example 51)
Affinity DataIC50:  558nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399921(Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-6,7-dihy...)
Affinity DataIC50:  653nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399940(US10323042, Example 20 | US10738063, Example 20)
Affinity DataIC50:  2.97E+3nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399964(US10323042, Example 44 | US10738063, Example 44)
Affinity DataIC50:  6.42E+3nMAssay Description:Beta-2 adrenergic receptor antagonistic activity on guinea pig tracheal chainsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399940(US10323042, Example 20 | US10738063, Example 20)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399952(US10323042, Example 32 | US10738063, Example 32)
Affinity DataIC50: >1.22E+4nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399947(US10323042, Example 27 | US10738063, Example 27)
Affinity DataIC50: >1.28E+4nMAssay Description:Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399923(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-6,7-...)
Affinity DataIC50: >1.51E+4nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399940(US10323042, Example 20 | US10738063, Example 20)
Affinity DataIC50: >1.70E+4nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399921(Azetidin-1-yl[3-(4-chloro-2-methylphenyl)-6,7-dihy...)
Affinity DataIC50: >2.98E+4nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399940(US10323042, Example 20 | US10738063, Example 20)
Affinity DataIC50: >3.00E+4nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed