Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50002374
LigandChemical structure of BindingDB Monomer ID 312809BDBM312809(US9605005, Example 98 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457820BDBM50457820(CHEMBL4216289)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457816BDBM50457816(CHEMBL4215425)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312763BDBM312763(US9605005, Example 52 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312785BDBM312785(US9605005, Example 74 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312765BDBM312765(US9605005, Example 54 | 5-fluoro-1-[4-[2-[(3R)-3-h...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312788BDBM312788(US9605005, Example 77 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312711BDBM312711(US9605005, Example 1 | 1-[3-[2-[(3R)-3-hydroxy-1- ...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312764BDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457815BDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312723BDBM312723(US9605005, Example 13 | 5-fluoro-1-[3-[2-[(3R)-3-h...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457818BDBM50457818(CHEMBL4211560)
Affinity DataKi:  0.420nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457817BDBM50457817(CHEMBL4214032)
Affinity DataKi:  0.590nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312762BDBM312762(US9605005, Example 51 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457812BDBM50457812(CHEMBL4217923)
Affinity DataKi:  1.30nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457811BDBM50457811(CHEMBL4210461)
Affinity DataKi:  2nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312809BDBM312809(US9605005, Example 98 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312799BDBM312799(US9605005, Example 88 | 3-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457813BDBM50457813(CHEMBL4210066)
Affinity DataKi:  5.90nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312794BDBM312794(US9605005, Example 83 | 5-amino-1-[4-[2-[(3R)-3-hy...)
Affinity DataKi:  9.40nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457816BDBM50457816(CHEMBL4215425)
Affinity DataIC50: 10nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312788BDBM312788(US9605005, Example 77 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312792BDBM312792(US9605005, Example 81 | 5-cyclopropyl-1-[4-[2-[(3R...)
Affinity DataKi:  16nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457820BDBM50457820(CHEMBL4216289)
Affinity DataIC50: 16nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312785BDBM312785(US9605005, Example 74 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312766BDBM312766(US9605005, Example 55 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  28nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312711BDBM312711(US9605005, Example 1 | 1-[3-[2-[(3R)-3-hydroxy-1- ...)
Affinity DataIC50: 29nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312763BDBM312763(US9605005, Example 52 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457815BDBM50457815(CHEMBL4211840)
Affinity DataIC50: 34nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312764BDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312723BDBM312723(US9605005, Example 13 | 5-fluoro-1-[3-[2-[(3R)-3-h...)
Affinity DataIC50: 39nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457814BDBM50457814(CHEMBL4212983)
Affinity DataKi:  68nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457817BDBM50457817(CHEMBL4214032)
Affinity DataIC50: 69nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457815BDBM50457815(CHEMBL4211840)
Affinity DataIC50: 70nMAssay Description:Inhibition of NIK in human HeLa cells assessed as inhibition of non-classical NFkB signaling by measuring reduction in nuclear translocation of p52 p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457818BDBM50457818(CHEMBL4211560)
Affinity DataIC50: 80nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312762BDBM312762(US9605005, Example 51 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 84nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457812BDBM50457812(CHEMBL4217923)
Affinity DataIC50: 170nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312765BDBM312765(US9605005, Example 54 | 5-fluoro-1-[4-[2-[(3R)-3-h...)
Affinity DataIC50: 220nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457819BDBM50457819(CHEMBL4206671)
Affinity DataKi:  350nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457811BDBM50457811(CHEMBL4210461)
Affinity DataIC50: 355nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50457813BDBM50457813(CHEMBL4210066)
Affinity DataIC50: 380nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312799BDBM312799(US9605005, Example 88 | 3-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312792BDBM312792(US9605005, Example 81 | 5-cyclopropyl-1-[4-[2-[(3R...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312794BDBM312794(US9605005, Example 83 | 5-amino-1-[4-[2-[(3R)-3-hy...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50457815BDBM50457815(CHEMBL4211840)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TNFalpha-induced nuclear translocation of NFkB RelA in human HeLa cells preincubated for 4.5 hrs followed by TNFalpha stimulation for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 312766BDBM312766(US9605005, Example 55 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed