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Found 14 Enz. Inhib. hit(s) with all data for entry = 50002770
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM150162(BI-10773 | Jardiance | US8980829, EMPAGLIFLOZIN | ...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396779(TOFOGLIFLOZIN)
Affinity DataIC50:  4nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462729(CHEMBL4238635)
Affinity DataIC50:  126nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462730(CHEMBL4248660)
Affinity DataIC50:  184nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462731(CHEMBL4238200)
Affinity DataIC50:  246nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462730(CHEMBL4248660)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462729(CHEMBL4238635)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462731(CHEMBL4238200)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed