Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50008300 Sort by
TargetCyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263013(CHEMBL4079206)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human CDK9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263013(CHEMBL4079206)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in insect cells after 2.5 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193086(CHEMBL3969723)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) after 30 mins in presence of [gamma-33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263013(CHEMBL4079206)
Affinity DataIC50: 23nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263013(CHEMBL4079206)
Affinity DataIC50: 45nMAssay Description:Inhibition of human CDK6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193086(CHEMBL3969723)
Affinity DataIC50: 63nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus expression system after 30 mins in presence of [gamma-33P]ATP by scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193104(CHEMBL3905910)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CDK6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193104(CHEMBL3905910)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CDK9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) using AAKAKKTPKKAKK-CONH2 as substrate after 20 mins by immunoprecipitation analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using AAKAKKTPKKAKK-CONH2 as substrate after 20 mins by immunoprecipitation analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193104(CHEMBL3905910)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193104(CHEMBL3905910)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK2/cyclinE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5710(2-[(2-chlorophenyl)sulfanyl]-5,7-dihydroxy-8-[(3S,...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human GST-tagged CDK1/cyclin B1 expressed in baculovirus after 45 mins in presence of [gamma-33P]ATP by liquid scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5711((3S,4R)-2-(2-Chlorophenoxy)-5,7-dihydroxy-8-(3-hyd...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human GST-tagged CDK1/cyclin B1 expressed in baculovirus after 45 mins in presence of [gamma-33P]ATP by liquid scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(CHEMBL16171 | 5,7-Dihydroxy-8-methoxy-2-phenyl-chr...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged CDK9 (2 to 372 residues) expressed in baculovirus infected Sf9 insect cells co-expressing human...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23408(2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-ch...)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7457(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-on...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7462(cid_5280863 | CHEMBL150 | 3,5,7-trihydroxy-2-(4-hy...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26656(5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chrome...)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 780nMAssay Description:Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(CHEMBL16171 | 5,7-Dihydroxy-8-methoxy-2-phenyl-chr...)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50517729(CHEMBL4454394)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human CDK2/cyclin E expressed in baculovirus expression system after 30 mins in presence of [gamma-33P]ATP by scintillation counting an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5710(2-[(2-chlorophenyl)sulfanyl]-5,7-dihydroxy-8-[(3S,...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human GST-tagged CDK2/cyclinE expressed in baculovirus after 45 mins in presence of [gamma-33P]ATP by liquid scintillation counting ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5711((3S,4R)-2-(2-Chlorophenoxy)-5,7-dihydroxy-8-(3-hyd...)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of human GST-tagged CDK2/cyclinE expressed in baculovirus after 45 mins in presence of [gamma-33P]ATP by liquid scintillation counting ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50049395(5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chr...)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193086(CHEMBL3969723)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human CDK2/cyclin E expressed in baculovirus expression system after 30 mins in presence of [gamma-33P]ATP by scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of protein kinase C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5711((3S,4R)-2-(2-Chlorophenoxy)-5,7-dihydroxy-8-(3-hyd...)
Affinity DataIC50: 6.15E+3nMAssay Description:Inhibition of human GST-tagged CDK4/cyclin D1 expressed in baculovirus after 1 hr in presence of [gamma-33P]ATP by liquid scintillation counting anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using AAKAKKTPKKAKK-CONH2 as substrate after 20 mins by immunoprecipitation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C zeta type(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of PKC in rat brain homogenate using FKKSFKL-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | cid_5281...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26658(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50009001(CHEMBL8260 | Baicalein | 5,6,7-Trihydroxyflavone |...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50140257(CHEMBL16171 | 5,7-Dihydroxy-8-methoxy-2-phenyl-chr...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged and N-terminal GST-tagged CDK7/cyclinH/MAT1 expressed in baculovirus Sf21 insect c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Erk-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5710(2-[(2-chlorophenyl)sulfanyl]-5,7-dihydroxy-8-[(3S,...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human GST-tagged CDK4/cyclin D1 expressed in baculovirus after 1 hr in presence of [gamma-33P]ATP by liquid scintillation counting anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50517730(CHEMBL4435200)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human CDK2/cyclin E expressed in baculovirus expression system after 30 mins in presence of [gamma-33P]ATP by scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of pp60 src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLa-related protein 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant P-TEFb expressed in baculovirus expression system after 10 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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