Compile Data Set for Download or QSAR
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Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50006964
TargetMetabotropic glutamate receptor 5(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase pim-1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50391948(CHEMBL2147767)
Affinity DataIC50:  2nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50391946(CHEMBL2147763)
Affinity DataIC50:  2nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50505077(CHEMBL4588064)
Affinity DataIC50:  2nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50391938(CHEMBL2147845)
Affinity DataIC50:  3nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMetabotropic glutamate receptor 5(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataIC50:  4nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50505076(CHEMBL4530560)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50113471(CHEMBL3603918)
Affinity DataIC50:  20nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50505078(CHEMBL4590482)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50391944(CHEMBL2147769)
Affinity DataIC50:  53nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50391949(CHEMBL2147768)
Affinity DataIC50:  92nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50505075(CHEMBL4443751)
Affinity DataIC50:  120nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM50391945(CHEMBL2147770)
Affinity DataIC50:  447nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  3.98E+4nMAssay Description:Binding affinity to cSRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase ABL2(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  10nMAssay Description:Binding affinity to ABL2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase ABL1(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  1nMAssay Description:Binding affinity to ABL1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetTyrosine-protein kinase Lck(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  40nMAssay Description:Binding affinity to LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  10nMAssay Description:Binding affinity to CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  13nMAssay Description:Binding affinity to KIT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLysine--tRNA ligase(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  3.16E+3nMAssay Description:Binding affinity to SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  0.794nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  3.16E+3nMAssay Description:Binding affinity to p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)