Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50007396
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50253154(N-Cyclopropyl-4-methyl-3-(1-(2-methylphenyl)-6-pht...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50253154(N-Cyclopropyl-4-methyl-3-(1-(2-methylphenyl)-6-pht...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50252739(N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethy...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509054(CHEMBL1232751)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50494296(CHEMBL3086685)
Affinity DataIC50: 1nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataKi:  1nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509055(CHEMBL4575052)
Affinity DataIC50: 1nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50348310(CHEMBL1800911 | US8772288, 1)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50331625(5-amino-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM20649(N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]am...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50296645(N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50361469(CHEMBL1938764)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50327020(4-(5-(Isoxazol-3-ylcarbamoyl)-2-methylphenylamino)...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50348880(CHEMBL1807446)
Affinity DataIC50: 4nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509059(CHEMBL4593539)
Affinity DataIC50: 7nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50492393(CHEMBL2401978)
Affinity DataIC50: 7nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataKi:  9nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50265033(N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxa...)
Affinity DataKi:  10nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509053(CHEMBL4535046)
Affinity DataIC50: 10nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50263093(N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methy...)
Affinity DataKi:  12nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50: 13nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50494296(CHEMBL3086685)
Affinity DataKd:  17nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50398148(CHEMBL2177219)
Affinity DataIC50: 35nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50361469(CHEMBL1938764)
Affinity DataIC50: 58nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509052(CHEMBL4580637)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50263093(N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methy...)
Affinity DataIC50: 75nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi:  240nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50418613(CHEMBL1232887)
Affinity DataIC50: 316nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25981(BMCL18324 Compound 17 | N-(cyclopropylmethyl)-4-[2...)
Affinity DataKi:  480nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509052(CHEMBL4580637)
Affinity DataIC50: 784nMAssay Description:Inhibition of full-length N-terminal GST-tagged human P38beta (1 to 364 residues) expressed in Escherichia coli using propeptide-8 as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509056(CHEMBL4450593)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509057(CHEMBL4514029)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509051(CHEMBL4585735)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25981(BMCL18324 Compound 17 | N-(cyclopropylmethyl)-4-[2...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50509058(CHEMBL4463733)
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed