Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50015607
LigandChemical structure of BindingDB Monomer ID 50587773BDBM50587773(CHEMBL5190946)
Affinity DataKd:  0.0130nMAssay Description:Binding affinity to human wild-type PKAc beta assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587766BDBM50587766(CHEMBL5199572)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to haspin (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587766BDBM50587766(CHEMBL5199572)
Affinity DataKd:  0.0190nMAssay Description:Binding affinity to a TEV-cleavable N-terminal His6-tagged human recombinant haspin (470 to 798 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50587772BDBM50587772(CHEMBL5185265)
Affinity DataKd:  0.0420nMAssay Description:Displacement of mAb(D38C6)-BTN from human recombinant PKAc alpha incubated for 15 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50587771BDBM50587771(CHEMBL5183651)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to PKA (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587782BDBM50587782(CHEMBL5209202)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to chicken 6-His tagged c-Src expressed in Escherichia coli Bl21 (DE3) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587779BDBM50587779(CHEMBL5194339)
Affinity DataKd:  0.420nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Haspin (470 to 798 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335638BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant CK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315480BDBM315480(US10172858, Table 1.4)
Affinity DataIC50: 2nMAssay Description:Inhibition of mTOR (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587785BDBM50587785(CHEMBL5178368)
Affinity DataIC50: 2nMAssay Description:Inhibition of haspin (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50587770BDBM50587770(CHEMBL5188493)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587781BDBM50587781(CHEMBL5169980)
Affinity DataKd:  4nMAssay Description:Binding affinity to a TEV-cleavable N-terminal His6-tagged human recombinant haspin (470 to 798 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119570BDBM50119570(CHEMBL3617731)
Affinity DataKi:  20nMAssay Description:Irreversible inhibition of wild type c-Src (unknown origin) assessed as inhibition constant by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50254739BDBM50254739(CHEMBL4079223)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant ERK2 expressed in Escherichia coli DH5alpha incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587771BDBM50587771(CHEMBL5183651)
Affinity DataKd:  30nMAssay Description:Inhibition of ROCK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507989BDBM50507989(CHEMBL4445670)
Affinity DataIC50: 35nMAssay Description:Activation of ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587774BDBM50587774(CHEMBL5203051)
Affinity DataIC50: 47nMAssay Description:Inhibition of CK2alpha in human MIA PaCa-2 cells incubated for 5 hrs by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119569BDBM50119569(CHEMBL3617733)
Affinity DataKi:  90nMAssay Description:Irreversible inhibition of wild type c-Src (unknown origin) assessed as inhibition constant by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Mouse)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507989BDBM50507989(CHEMBL4445670)
Affinity DataIC50: 120nMAssay Description:Activation of ERK5 in MEF cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587778BDBM50587778(CHEMBL5198165)
Affinity DataKd:  150nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Haspin (470 to 798 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14027BDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 158nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50587769BDBM50587769(CHEMBL5181354)
Affinity DataIC50: 159nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587784BDBM50587784(CHEMBL5202249)
Affinity DataIC50: 160nMAssay Description:Inhibition of c-Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587780BDBM50587780(CHEMBL5209851)
Affinity DataKd:  170nMAssay Description:Binding affinity to N-terminal his6-tagged human recombinant Haspin (470 to 798 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEphrin type-A receptor 3(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587767BDBM50587767(CHEMBL5172097)
Affinity DataKd:  250nMAssay Description:Inhibition of EPHA3 (unknown origin) assessed as dissociation constant by ELISA-like binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50142887BDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataKd:  296nMAssay Description:Binding affinity to chicken 6-His tagged c-Src expressed in Escherichia coli Bl21 (DE3) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587775BDBM50587775(CHEMBL5192851)
Affinity DataIC50: 670nMAssay Description:Inhibition of human CK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587777BDBM50587777(CHEMBL5174190)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant ERK2 expressed in Escherichia coli DH5alpha incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587783BDBM50587783(CHEMBL5206201)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of c-Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 14027BDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50587776BDBM50587776(CHEMBL5184966)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331791BDBM50331791((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...)
Affinity DataKd: >1.50E+4nMAssay Description:Binding affinity to a TEV-cleavable N-terminal His6-tagged human recombinant haspin (470 to 798 residues) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50587768BDBM50587768(CHEMBL5172395)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEphrin type-A receptor 3(Human)
Cha University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50142887BDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataKd:  2.00E+5nMAssay Description:Inhibition of EPHA3 (unknown origin) assessed as dissociation constant by ELISA-like binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed