Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50014371
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575333BDBM50575333(CHEMBL4857063)
Affinity DataIC50: 8nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575331BDBM50575331(CHEMBL4868242)
Affinity DataIC50: 11nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575332BDBM50575332(CHEMBL4869725)
Affinity DataIC50: 14nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575328BDBM50575328(CHEMBL4868367)
Affinity DataIC50: 32nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387265BDBM387265(US10292981, Example 33 | 2,6- Difluoro-N-(2′...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575327BDBM50575327(CHEMBL4848840)
Affinity DataIC50: 34nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575326BDBM50575326(CHEMBL4868517)
Affinity DataIC50: 50nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575329BDBM50575329(CHEMBL4859192)
Affinity DataIC50: 55nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387270BDBM387270(US10292981, Example 87 | 2,6- Difluoro-N-(5-(2- me...)
Affinity DataIC50: 64nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387269BDBM387269(US10292981, Example 80 | 2- Chloro-N-(5-(5-(5,5- d...)
Affinity DataIC50: 65nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387261BDBM387261(US10292981, Example 3 | N-(5′- (5,5-Dimethyl...)
Affinity DataIC50: 69nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575331BDBM50575331(CHEMBL4868242)
Affinity DataIC50: 76nMAssay Description:Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual pat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387266BDBM387266(US10292981, Example 34 | N-(5′- (4-Ethyl-5-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387272BDBM387272(US10292981, Example 114 | N-(5-(5- (5,5-dimethyl-4...)
Affinity DataIC50: 94nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575336BDBM50575336(CHEMBL4753998)
Affinity DataIC50: 119nMAssay Description:Inhibition of Orai1/STIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387297BDBM387297(US10292981, Example 121)
Affinity DataIC50: 150nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387294BDBM387294(US10292981, Example 78)
Affinity DataIC50: 171nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387281BDBM387281(US10292981, Example 4 | N-(5-(5- (5,5-Dimethyl-4-o...)
Affinity DataIC50: 178nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575331BDBM50575331(CHEMBL4868242)
Affinity DataIC50: 183nMAssay Description:Inhibition of IL2 in thapsigargin stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575330BDBM50575330(CHEMBL4872805)
Affinity DataIC50: 227nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-2(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 387290BDBM387290(US10292981, Example 53 | N-(5- (5,5-Dimethyl-4,5- ...)
Affinity DataIC50: 328nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Lupin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575331BDBM50575331(CHEMBL4868242)
Affinity DataIC50: 695nMAssay Description:Inhibition of TNF-alpha in thapsigargin stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575336BDBM50575336(CHEMBL4753998)
Affinity DataIC50: 895nMAssay Description:Inhibition of Orai2/STIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575334BDBM50575334(CHEMBL4863881)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual pat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575335BDBM50575335(CHEMBL4570175)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human STIM1/Orai1 expressed in HEK293 cells assessed as reduction in Orai1 current by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575335BDBM50575335(CHEMBL4570175)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human STIM1/Orai3 expressed in HEK293 cells assessed as reduction in Orai3 current by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50575331BDBM50575331(CHEMBL4868242)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by FLIPR TETRA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed