Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50015159
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583383(CHEMBL5028005 | US20230339856, Compound (IIb3))
Affinity DataKi:  4.70nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583382(CHEMBL5028265)
Affinity DataKi:  6.10nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583381(CHEMBL5029066 | US20230339856, Compound (IIb1))
Affinity DataKi:  19nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583380(CHEMBL5027974)
Affinity DataKi:  37nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataKi:  59nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583379(CHEMBL5028138 | US20230339856, Compound (IIb))
Affinity DataKi:  59nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18353((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Affinity DataKi:  59nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50335398(N-Heptyl-1-deoxynojirimycin | CHEMBL1651551)
Affinity DataKi:  95nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18356((2R,3R,4R,5S)-1-hexyl-2-(hydroxymethyl)piperidine-...)
Affinity DataKi:  130nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50065258(CHEMBL314772 | (2S,3R,4S,5R)-2-methylpiperidine-3,...)
Affinity DataIC50: 140nMAssay Description:Inhibition of placental alpha-L-fucosidase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18355(N-Butyl-DNJ | (2R,3R,4R,5S)-1-butyl-2-(hydroxymeth...)
Affinity DataKi:  200nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583384(CHEMBL5080975)
Affinity DataKi:  210nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50335399(N-Pentyl-1-deoxynojirimycin | CHEMBL1651549)
Affinity DataKi:  210nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18354((2R,3R,4R,5S)-2-(hydroxymethyl)-1-propylpiperidine...)
Affinity DataKi:  360nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50399650(CHEMBL2177689)
Affinity DataIC50: 660nMAssay Description:Inhibition of rat intestinal sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50375511(CHEMBL406973)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Sucrase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583385(CHEMBL5028105)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583378(CHEMBL5028084 | US20230339856, Compound (IIa))
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50583377(CHEMBL5028072)
Affinity DataKi:  3.70E+4nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed