Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50017991
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450701(CHEMBL4168274)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human Hsp90alpha expressed in Escherichia coli BL21(DE3) incubated for 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606768(CHEMBL5220579)
Affinity DataKd:  2.77E+4nMAssay Description:Inhibition of human recombinant Hsp90beta expressed in Escherichia coli BL21(DE3) incubated for 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606768(CHEMBL5220579)
Affinity DataKd:  520nMAssay Description:Inhibition of human recombinant Hsp90alpha (1 to 223 residues) expressed in Escherichia coli BL21(DE3) incubated for 24 hrs by fluorescence polarizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606767(CHEMBL5220067)
Affinity DataKd:  7.26E+5nMAssay Description:Binding affinity to recombinant human Hsp90beta incubated for 30 mins by intrinsic fluorescence SpectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606767(CHEMBL5220067)
Affinity DataKd:  1.91E+5nMAssay Description:Binding affinity to recombinant human Hsp90alpha incubated for 30 mins by intrinsic fluorescence SpectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEndoplasmin(Dog)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450701(CHEMBL4168274)
Affinity DataKd:  440nMAssay Description:Binding affinity to dog GRP94 expressed in Escherichia coli BL21(DE3) incubated for 5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataKd:  1.40E+4nMAssay Description:Inhibition of human N-terminal His-tagged Hsp90alpha (1 to 236 residues) expressed in Escherichia coli BL21(DE3) measured after 24 hrs by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEndoplasmin(Dog)
Shandong University

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataKd:  2.80E+3nMAssay Description:Inhibition of N-terminal full length dog GRP94 (73 to 754 residues) expressed in Escherichia coli BL21(DE3) measured after 24 hrs by fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEndoplasmin(Dog)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataKd:  3.92E+4nMAssay Description:Binding affinity to dog GRP94 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50450703(CHEMBL4159086 | US11028041, Compound 30)
Affinity DataKd:  540nMAssay Description:Binding affinity to Hsp90alpha (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEndoplasmin(Dog)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50165286(8-(2,4-Dimethyl-phenylsulfanyl)-9-pent-4-ynyl-9H-p...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of dog cy3B-GM labeled GRP94 expressed in Escherichia coli BL21(DE3) measured after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM15374(CHEMBL113690 | 9-butyl-8-(3,4,5-trimethoxybenzyl)-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Her2 in human MCF7 cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50165286(8-(2,4-Dimethyl-phenylsulfanyl)-9-pent-4-ynyl-9H-p...)
Affinity DataIC50: 5.41E+4nMAssay Description:Inhibition of PU-FITC3 labeled Trap-1 (unknown origin) measured after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50165286(8-(2,4-Dimethyl-phenylsulfanyl)-9-pent-4-ynyl-9H-p...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human cy3B-GM labeled Hsp90beta expressed in Escherichia coli BL21(DE3) measured after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50165286(8-(2,4-Dimethyl-phenylsulfanyl)-9-pent-4-ynyl-9H-p...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human cy3B-GM labeled Hsp90alpha expressed in Escherichia coli BL21(DE3) measured after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606766(CHEMBL5218680)
Affinity DataKi:  21nMAssay Description:Binding affinity to recombinant human Hsp90beta assessed as inhibition constant incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606766(CHEMBL5218680)
Affinity DataKi:  35nMAssay Description:Binding affinity to recombinant human Hsp90alpha assessed as inhibition constant incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEndoplasmin(Dog)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606766(CHEMBL5218680)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant dog GRP94 assessed as inhibition constant incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50606766(CHEMBL5218680)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human TRAP1 assessed as inhibition constant incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed