Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 50016181
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593006BDBM50593006(CHEMBL5206237)
Affinity DataIC50: 0.708nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593011BDBM50593011(CHEMBL5208208)
Affinity DataIC50: 1nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593023BDBM50593023(CHEMBL5183504)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593017BDBM50593017(CHEMBL5196305)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069989BDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069989BDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398609BDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593025BDBM50593025(CHEMBL5187619)
Affinity DataIC50: 3nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593018BDBM50593018(CHEMBL5171338)
Affinity DataIC50: 3nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593007BDBM50593007(CHEMBL5176191)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593019BDBM50593019(CHEMBL5169581)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593026BDBM50593026(CHEMBL5198837)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593026BDBM50593026(CHEMBL5198837)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593009BDBM50593009(CHEMBL5206815)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593016BDBM50593016(CHEMBL5195292)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593021BDBM50593021(CHEMBL5181924)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593022BDBM50593022(CHEMBL5186813)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593010BDBM50593010(CHEMBL5198758)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593024BDBM50593024(CHEMBL5174430)
Affinity DataIC50: 6nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593001BDBM50593001(CHEMBL5188468)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593013BDBM50593013(CHEMBL483266)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593008BDBM50593008(CHEMBL5207483)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593020BDBM50593020(CHEMBL5177370)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593012BDBM50593012(CHEMBL5182924)
Affinity DataIC50: 12nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593015BDBM50593015(CHEMBL5182795)
Affinity DataIC50: 13nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593004BDBM50593004(CHEMBL5182548)
Affinity DataIC50: 19nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50155926BDBM50155926(CHEMBL3183703)
Affinity DataIC50: 22nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593014BDBM50593014(CHEMBL5180570)
Affinity DataIC50: 32nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593017BDBM50593017(CHEMBL5196305)
Affinity DataIC50: 32nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069989BDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 41nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593025BDBM50593025(CHEMBL5187619)
Affinity DataIC50: 46nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593023BDBM50593023(CHEMBL5183504)
Affinity DataIC50: 49nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593013BDBM50593013(CHEMBL483266)
Affinity DataIC50: 49nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593000BDBM50593000(CHEMBL5208745)
Affinity DataIC50: 50nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592999BDBM50592999(CHEMBL5183945)
Affinity DataIC50: 50nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593002BDBM50593002(CHEMBL5187280)
Affinity DataIC50: 50nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593003BDBM50593003(CHEMBL5199078)
Affinity DataIC50: 50nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593005BDBM50593005(CHEMBL5178579)
Affinity DataIC50: 50nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593016BDBM50593016(CHEMBL5195292)
Affinity DataIC50: 65nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593018BDBM50593018(CHEMBL5171338)
Affinity DataIC50: 74nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593020BDBM50593020(CHEMBL5177370)
Affinity DataIC50: 76nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593011BDBM50593011(CHEMBL5208208)
Affinity DataIC50: 79nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593009BDBM50593009(CHEMBL5206815)
Affinity DataIC50: 81nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593021BDBM50593021(CHEMBL5181924)
Affinity DataIC50: 85nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593001BDBM50593001(CHEMBL5188468)
Affinity DataIC50: 87nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593024BDBM50593024(CHEMBL5174430)
Affinity DataIC50: 91nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-2(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593026BDBM50593026(CHEMBL5198837)
Affinity DataIC50: 101nMAssay Description:Inhibition of 20S proteasome beta2 subunit (unknown origin) using Boc-LRR-AMC as flurogenic substrate measured after 1 hr by fluorescence based analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-1(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593026BDBM50593026(CHEMBL5198837)
Affinity DataIC50: 114nMAssay Description:Inhibition of 20S proteasome beta1 subunit (unknown origin) using Z-LLE-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593022BDBM50593022(CHEMBL5186813)
Affinity DataIC50: 141nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593019BDBM50593019(CHEMBL5169581)
Affinity DataIC50: 151nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
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