Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50016192
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataKd:  33nMAssay Description:Binding affinity to NTMT1 (unknown origin) assessed as dissociation constant in presence of SAM by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataKd:  160nMAssay Description:Binding affinity to NTMT1 (unknown origin)assessed as dissociation constant in absence of SAM by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-SET level incubated for 72 hrs by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-RCC1 level incubated for 72 hrs by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60981BDBM60981(SCH-202676 hydrobromide | SMR001230740 | MLS002153...)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length His-NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by Mtase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataIC50: 500nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by SAHH-coup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataIC50: 500nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by SAHH-coup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataIC50: 560nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production by SAHH-coup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593123BDBM50593123(Venglustat | Genz-682452 | Gz402671 | Ibiglustat |...)
Affinity DataIC50: 560nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593129BDBM50593129(CHEMBL5186713)
Affinity DataIC50: 910nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593130BDBM50593130(CHEMBL5195898)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593124BDBM50593124(CHEMBL5207416)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593131BDBM50593131(CHEMBL5207800)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593128BDBM50593128(CHEMBL5173209)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593132BDBM50593132(CHEMBL5190365)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593125BDBM50593125(CHEMBL5205982)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593127BDBM50593127(CHEMBL5173370)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593126BDBM50593126(CHEMBL5187805)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593133BDBM50593133(CHEMBL5206916)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593134BDBM50593134(CHEMBL5170768)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using GPKRIA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed