Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50018140
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse DRG neuron Nav1.7 at -70 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Nav1.5 at -60 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Nav1.7 by 5-Hz use-dependent voltage protocol based automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of mouse Nav1.7 at -70 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse Nav1.7 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human Nav1.7 at voltage yielding 20 to 50% channel inactivation by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse Nav1.7 by 5-Hz use-dependent voltage protocol based automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse Nav1.7 at voltage yielding 20 to 50% channel inactivation by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50466964(Pf-05241328)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Nav1.7 in inactivated condition by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405441(CHEMBL5286125)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Nav1.7 in inactivated condition by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 54nMAssay Description:Inhibition of human Nav1.7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405442(CHEMBL5289676)
Affinity DataIC50: 66nMAssay Description:Inhibition of human Nav1.7 at voltage yielding 20% channel inactivation by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 84nMAssay Description:Inhibition of human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50118492(CHEMBL3617056)
Affinity DataIC50: 90nMAssay Description:Inhibition of human Nav1.7 in inactivated condition by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.1 at -45 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 173nMAssay Description:Inhibition of Nav1.6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataIC50: 192nMAssay Description:Inhibition of human Nav1.1 at -45 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataIC50: 192nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Rat)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50349984(CHEMBL1813048)
Affinity DataIC50: 390nMAssay Description:Inhibition of rat Nav1.7 in 20% inactivated condition by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataIC50: 435nMAssay Description:Inhibition of human Nav1.5 at -60 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM206760(US9695185, I-S | US9260446, (I-S))
Affinity DataIC50: 601nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataIC50: 970nMAssay Description:In vivo inhibition of Nav1.7 in IEM mouse model of aconitine-induced painMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human Nav1.5 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405439(CHEMBL5275826)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human Nav1.7 at -30 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataIC50: 7.30E+3nMAssay Description:In vivo inhibition of Nav1.7 in IEM mouse model of aconitine-induced painMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50117271(CHEMBL558 | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethy...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of human Nav1.7 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405442(CHEMBL5289676)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human Nav1.1 at voltage yielding 20% channel inactivation by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405439(CHEMBL5275826)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of mouse Nav1.7 at -30 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human Nav1.1 by 5-Hz use-dependent voltage protocol based automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human Nav1.5 by 5-Hz use-dependent voltage protocol based automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50117271(CHEMBL558 | 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human Nav1.5 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of human Nav1.1 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50017662(CHEMBL79 | N-(2,6-dimethylphenyl)-N(2),N(2)-diethy...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human Nav1.7 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405442(CHEMBL5289676)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Nav1.5 at voltage yielding 20% channel inactivation by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of human Nav1.5 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50017662(CHEMBL79 | N-(2,6-dimethylphenyl)-N(2),N(2)-diethy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human Nav1.5 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataIC50: 9.13E+4nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405439(CHEMBL5275826)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.1 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50405439(CHEMBL5275826)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.5 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.1 at -60 mV holding potential by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50300204((R)-N-benzyl 2-acetamido-3-methoxypropionamide, | ...)
Affinity DataIC50: 1.82E+5nMAssay Description:Inhibition of human Nav1.7 in inactivated condition by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)