Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50018542
TargetSurvival motor neuron protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465925(CHEMBL4283367)
Affinity DataEC50:  4nMAssay Description:Modulation of human SMN2 level in NSC34 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSurvival motor neuron protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465914(Branaplam | LMI-070 | LMI070)
Affinity DataEC50:  20nMAssay Description:Modulation of human SMN2 level in NSC34 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSurvival motor neuron protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465920(CHEMBL4280558)
Affinity DataEC50:  20nMAssay Description:Modulation of human SMN2 level in NSC34 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSurvival motor neuron protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465921(CHEMBL4288439)
Affinity DataEC50:  30nMAssay Description:Modulation of human SMN2 level in NSC34 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50099062(CHEMBL3344081 | US10730870, Example 3 | US11512083...)
Affinity DataKd:  185nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465921(CHEMBL4288439)
Affinity DataIC50: 230nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465920(CHEMBL4280558)
Affinity DataIC50: 300nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSurvival motor neuron protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465931(CHEMBL4290774)
Affinity DataEC50:  340nMAssay Description:Modulation of human SMN2 level in NSC34 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50099144(CHEMBL3344079)
Affinity DataKd:  3.27E+3nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSurvival motor neuron protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465913(CHEMBL4278935)
Affinity DataEC50:  3.30E+3nMAssay Description:Modulation of human SMN2 level in NSC34 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataIC50: 4.10E+3nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) by fluorescence polarization (FP) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465931(CHEMBL4290774)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465925(CHEMBL4283367)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465914(Branaplam | LMI-070 | LMI070)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50099147(CHEMBL3343404)
Affinity DataKd:  2.22E+4nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50465913(CHEMBL4278935)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50609394(CHEMBL5266076)
Affinity DataKd:  4.55E+4nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50609394(CHEMBL5266076)
Affinity DataIC50: 5.32E+4nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) by fluorescence polarization (FP) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50014095(CHEMBL3260850)
Affinity DataIC50: 1.17E+5nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) by fluorescence polarization (FP) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed