Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50019559
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620491(CHEMBL5416793)
Affinity DataIC50: 3nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataIC50: 5nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50514402(CHEMBL4535757 | US11345701, Compound Amg-510)
Affinity DataIC50: 7nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620492(CHEMBL5417514)
Affinity DataIC50: 15nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620510(CHEMBL5395862)
Affinity DataIC50: 16nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620511(CHEMBL5431111)
Affinity DataIC50: 19nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620508(CHEMBL5434387)
Affinity DataIC50: 22nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620502(CHEMBL5425389)
Affinity DataIC50: 29nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620501(CHEMBL5436538)
Affinity DataIC50: 43nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620503(CHEMBL5411433)
Affinity DataIC50: 74nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620504(CHEMBL5431716)
Affinity DataIC50: 81nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50521250(CHEMBL4475526)
Affinity DataIC50: 82nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620500(CHEMBL5397175)
Affinity DataIC50: 90nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620506(CHEMBL5396905)
Affinity DataIC50: 99nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620507(CHEMBL5440242)
Affinity DataIC50: 110nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620509(CHEMBL5397270)
Affinity DataIC50: 130nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620498(CHEMBL5423732)
Affinity DataIC50: 149nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620505(CHEMBL5399669)
Affinity DataIC50: 160nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620497(CHEMBL5434277)
Affinity DataIC50: 231nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620499(CHEMBL5439404)
Affinity DataIC50: 279nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620495(CHEMBL5417255)
Affinity DataIC50: 332nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620494(CHEMBL5431650)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620496(CHEMBL5411023)
Affinity DataIC50: 4.01E+3nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620493(CHEMBL5418874)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620512(CHEMBL5434304)
Affinity DataIC50: 7.82E+3nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620496(CHEMBL5411023)
Affinity DataIC50: 8.29E+3nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50620513(CHEMBL5436936)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed