Compile Data Set for Download or QSAR
Report error Found 117 Enz. Inhib. hit(s) with all data for entry = 50019324
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataKi:  0.00900nMAssay Description:Binding affinity to HDAC2 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618122(CHEMBL5413269)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to HDAC3 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50082325(CHEMBL99392)
Affinity DataKi:  0.130nMAssay Description:Binding affinity to HDAC2 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50082325(CHEMBL99392)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19423(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidoben...)
Affinity DataKi: <0.200nMAssay Description:Binding affinity to recombinant human HDAC1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM198122(HC toxin)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618122(CHEMBL5413269)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618122(CHEMBL5413269)
Affinity DataKi:  0.350nMAssay Description:Binding affinity to HDAC2 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM198122(HC toxin)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataKi:  0.470nMAssay Description:Binding affinity to HDAC2 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50082325(CHEMBL99392)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to HDAC1 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19423(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidoben...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1nMAssay Description:Inhibition of human HDAC3/NCOR2 using Acetyl-Lys(Ac)-AMC as substrate measured after 1 hrs by fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to HDAC2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM198122(HC toxin)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to HDAC2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to HDAC3 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50082325(CHEMBL99392)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19423(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidoben...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to recombinant human HDAC2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618122(CHEMBL5413269)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to recombinant human HDAC3 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to recombinant human HDAC1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 2nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human HDAC1 expressed in HEK293F cells measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataIC50: 2nMAssay Description:Inhibition of human HDAC1 measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  3nMAssay Description:Binding affinity to human HDAC1 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to HDAC2 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618125(CHEMBL5427613)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to N-terminal GST-tagged human full length HDAC6 expressed in baculovirus infected Sf9 cells using Fluor-de-Lys Green as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human HDAC1 expressed in HEK293F cells measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  5nMAssay Description:Binding affinity to human HDAC3 using Acetyl-Lys(Ac)-AMC as substrate assessed as inhibition constant measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity to recombinant human HDAC1 expressed in baculovirus infected HEK293T cells using acetylLys(Ac)-AMC as substrate assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618121(CHEMBL5410602)
Affinity DataKi:  7nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity to HDAC8 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50618125(CHEMBL5427613)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of N-terminal GST-tagged human full length HDAC6 expressed in baculovirus infected Sf9 cells using Fluor-de-Lys Green as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataKi:  7.80nMAssay Description:Binding affinity to recombinant human HDAC3 expressed in baculovirus infected HEK293T cells using acetylLys(Ac)-AMC as substrate assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM19423(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidoben...)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM198122(HC toxin)
Affinity DataKi:  10nMAssay Description:Binding affinity to HDAC2 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  12nMAssay Description:Binding affinity to C-terminal His-tagged human HDAC2 (2 to 488 residues) in transfected in baculovirus infected Sf9 cells assessed as dissociation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM198122(HC toxin)
Affinity DataKi:  14nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207628(US9265734, RGFA8 | US9796664, Compound RGFA8)
Affinity DataKi:  14nMAssay Description:Binding affinity to recombinant human HDAC3 expressed in baculovirus infected HEK293T cells using acetylLys(Ac)-AMC as substrate assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nMAssay Description:Binding affinity to human HDAC2 assessed as inhibition constant measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50229189([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 15nMAssay Description:Inhibition of C-terminal flag-tagged recombinant human HDAC1 expressed in HEK293F cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataKi:  15nMAssay Description:Binding affinity to HDAC3 (unknown origin) using Ac-LGKac-AMC as substrate assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  15nMAssay Description:Binding affinity to human HDAC1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
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