Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50021579
TargetVascular endothelial growth factor receptor 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by kinase profiling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50642136(CHEMBL5562761)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by kinase profiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of wild type human PDGFRalpha transfected with CHO cells by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ABL (unknown origin) by kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM734434(US20250129067, Compound Anlotinib)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of c-Met (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50642133(CHEMBL5565411)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by kinase profiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50049189(butyl 3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to AT2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 30 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetType-1 angiotensin II receptor(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50049189(butyl 3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to AT1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642136(CHEMBL5562761)
Affinity DataIC50: 7nMAssay Description:Inhibition of AKT phosphorylation in human OVCAR-8 cells assessed as reduction in pAKT level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 7nMAssay Description:Inhibition of AXL (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50642134(CHEMBL1234114)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by kinase profiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642132(CHEMBL5574484)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human recombinant DDR2 using poly(Glu,Tyr) as substrate incubated for 1 hr by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50642135(CHEMBL5571102)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by kinase profiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 12nMAssay Description:Inhibition of DDR1 (unknown origin) in presence of ATP by Z-Lyte enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 19nMAssay Description:Inhibition of DDR2 (unknown origin) in presence of ATP by Z-Lyte enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642130(CHEMBL5592453)
Affinity DataIC50: 25nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642131(CHEMBL5591364)
Affinity DataIC50: 31nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetfMet-Leu-Phe receptor(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM523339(US11136296, Example 70)
Affinity DataIC50: 32nMAssay Description:Inhibition of human FPR expressed in human U-937 cells by fluorescence based ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642133(CHEMBL5565411)
Affinity DataIC50: 40nMAssay Description:Inhibition of AKT phosphorylation in human OVCAR-8 cells assessed as reduction in pAKT level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 41nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 42nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642135(CHEMBL5571102)
Affinity DataIC50: 49nMAssay Description:Inhibition of AKT phosphorylation in human OVCAR-8 cells assessed as reduction in pAKT level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642134(CHEMBL1234114)
Affinity DataIC50: 76nMAssay Description:Inhibition of AKT phosphorylation in human OVCAR-8 cells assessed as reduction in pAKT level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 85nMAssay Description:Inhibition of glutathione S-transferase fused PDGFbetaR (unknown origin) in 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642130(CHEMBL5592453)
Affinity DataIC50: 100nMAssay Description:Inhibition of glutathione S-transferase fused PDGFbetaR (unknown origin) in 3T3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642130(CHEMBL5592453)
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642131(CHEMBL5591364)
Affinity DataIC50: 135nMAssay Description:Inhibition of wild type human PDGFRalpha transfected with CHO cells by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM12244(N-(2-chloro-5-methoxyphenyl)-6,7-dimethoxyquinazol...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant c-SRC catalytic domain using pEY (4:1) as substrate incubated for 30 mins in presence of ATP by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50642130(CHEMBL5592453)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Binding affinity to STAT3 in human NIH-3T3 cells assessed as STAT3 stabilization incubated for 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetType-1 angiotensin II receptor(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to AT1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed