Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50022423
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR1 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50506458(CHEMBL4576115)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50460035(CHEMBL4227505)
Affinity DataIC50: 1nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652115(CHEMBL5647404)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of c-Kit (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CSF1-induced CSF1R signalling in mouse BMDM cells assessed as reduction in ERK1/2 phosphorylation preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of FGFR3 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1R (unknown origin) incubated for 1 hrs by Z'-LYTE Kinase assay kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of KIT (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50312743(3-(5-methoxy-6-(4-methoxybenzyloxy)pyridin-3-yloxy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652111(CHEMBL5646924)
Affinity DataIC50: 12nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652110(CHEMBL5639687)
Affinity DataIC50: 14nMAssay Description:Inhibition of CSF1R (unknown origin) using ATP as substrate incubated for 1 hr by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 15nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 15nMAssay Description:Inhibition of AXL (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50289371(CHEMBL4160143)
Affinity DataIC50: 15nMAssay Description:Inhibition of FMS (unknown origin) by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAurora kinase C(Human)TBA
LigandPNGBDBM50652114(CHEMBL5639882)
Affinity DataIC50: 16nMAssay Description:Inhibition of human AURKC by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652109(Pimicotinib | ABSK-021 FREE BASE ANHYDROUS | ABSK-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of CSF1R (unknown origin) using ATP as substrate incubated for 1 hr by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of TRKC (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 24nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP incubated for 45 mins by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652112(CHEMBL5646587)
Affinity DataIC50: 30nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50146163(CHEMBL3764045)
Affinity DataIC50: 32nMAssay Description:Inhibition of c-Met (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 41nMAssay Description:Inhibition of TRKB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 51nMAssay Description:Inhibition of FGFR4 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652110(CHEMBL5639687)
Affinity DataIC50: 60nMAssay Description:Inhibition of KIT (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human FMS by Z'-Lyte kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)
Affinity DataIC50: 67nMAssay Description:Inhibition of FLT3 (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652109(Pimicotinib | ABSK-021 FREE BASE ANHYDROUS | ABSK-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of KIT (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50319500(N-(3-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)ph...)
Affinity DataIC50: 96nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652108(CHEMBL5639336)
Affinity DataIC50: 110nMAssay Description:Inhibition of FMS (unknown origin) by biochemical hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 160nMAssay Description:Inhibition of FLT3 (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 190nMAssay Description:Inhibition of FLT3 (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 350nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP incubated for 45 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652114(CHEMBL5639882)
Affinity DataIC50: 390nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652110(CHEMBL5639687)
Affinity DataIC50: 435nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 860nMAssay Description:Inhibition of LCK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652114(CHEMBL5639882)
Affinity DataIC50: 860nMAssay Description:Inhibition of KIT (unknown origin) using ATP as substrate incubated for 1 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 880nMAssay Description:Inhibition of FLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 890nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAurora kinase C(Human)TBA
LigandPNGBDBM50652114(CHEMBL5639882)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AURKC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652114(CHEMBL5639882)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652109(Pimicotinib | ABSK-021 FREE BASE ANHYDROUS | ABSK-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652113(CHEMBL5646574)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of c-Kit (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50652113(CHEMBL5646574)
Affinity DataIC50: 5.78E+4nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed