Compile Data Set for Download or QSAR
Report error Found 103 Enz. Inhib. hit(s) with all data for entry = 50021121
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483418(US10919911, Example 40)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483388(US10919911, Example 10)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637214(CHEMBL5561248)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant ASK1 by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637210(CHEMBL5563790)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ASK1 (unknown origin) preincubated with compound for 30 mins followed by ATP addition and measured after 120 mins by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM464015(WX005 | US10787435, Example 005)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637192(CHEMBL5559907)
Affinity DataIC50: 1nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523870(US11136324, Example 10 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637195(CHEMBL5565908)
Affinity DataIC50: 1nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637193(CHEMBL5559017)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637194(CHEMBL5562336)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637208(CHEMBL5567699)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ASK1 (unknown origin) preincubated with compound for 30 mins followed by ATP addition and measured after 120 mins by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637211(CHEMBL5532500)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ASK1 (unknown origin) preincubated with compound for 30 mins followed by ATP addition and measured after 120 mins by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637187(CHEMBL5559945)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637189(CHEMBL5523506)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523868(US11136324, Example 8 | (R)-5-(4-Cyclopropyl-1H-im...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM463987(WX001 | US10787435, Example 001)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523892(US11136324, Example 55 | (R)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637218(CHEMBL5560758)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal his-tagged human ASK1 (649 to 946 residues) expressed in Escherichia coli using [gamma-32p]ATP as substrate by liquid scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50212258(GS-4997 | Selonsertib)
Affinity DataEC50:  2nMAssay Description:Inhibition of ASK1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM463999(WX002 | US10787435, Example 002 | US11117891, Exam...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483413(US10919911, Example 35)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM464011(WX004 | US10787435, Example 004)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523894(US11136324, Example 59 | (R)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM517576(USRE48711, Example 184 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50212258(GS-4997 | Selonsertib)
Affinity DataIC50: 3nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483410(US10919911, Example 32)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637190(CHEMBL5565439)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM517610(USRE48711, Example 218 | 3-(4-cyclopropyl-1H-imida...)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of ASK1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637207(CHEMBL5560015)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637191(CHEMBL5559626)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637200(CHEMBL5561877)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50505937(CHEMBL4514925 | US11168095, Example 91)
Affinity DataIC50: 4nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523883(US11136324, Example 38 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483412(US10919911, Example 34)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637206(CHEMBL5517887)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637209(CHEMBL5556181)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of ASK1 (unknown origin) preincubated with compound for 30 mins followed by ATP addition and measured after 120 mins by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483406(US10919911, Example 28)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523878(US11136324, Example 32 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523893(US11136324, Example 56 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50212258(GS-4997 | Selonsertib)
Affinity DataIC50: 5nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM523869(US11136324, Example 9 | (S)-5-(4-Cyclopropyl-1H-im...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 0.5 to 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM517610(USRE48711, Example 218 | 3-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637191(CHEMBL5559626)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50637220(CHEMBL5565976)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of N-terminal his-tagged human ASK1 (649 to 946 residues) expressed in Escherichia coli using [gamma-32p]ATP as substrate by liquid scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483394(US10919911, Example 16)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483423(US10919911, Example 45)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM504320(WX002 | US11040968, Example 002 | US11136324, Exam...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of full length GST-tagged recombinant human ASK1 using MBP as substrate incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483387(US10919911, Example 9)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483419(US10919911, Example 41)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM483379(US10919911, Example 1)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of ASK1 (unknown origin) incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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