Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 50021146
TargetPatatin-like phospholipase domain-containing protein 2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50387298(CHEMBL2048872)
Affinity DataKi:  0.0170nMAssay Description:Inhibition of ATGL ubiquitination in human HepG2 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTOR (unknown origin) by lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTranslocator protein(Rat)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50279753(2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of rat TSPOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50308135(PKI-587 | 1-(4-{[4-(Dimethylamino)piperidin-1-yl]c...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of mTOR (unknown origin) by lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTranslocator protein(Mouse)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50054139((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mouse TSPO expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTranslocator protein(Rat)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat TSPOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTranslocator protein(Rat)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50083351(4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phen...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of rat TSPOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTranslocator protein(Mouse)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50017376(1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse TSPOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PIK3C3 using PI as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFerritin heavy chain(Homo sapiens)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50241720((-)-Caryophyllene oxide | (1R,4R,5R,9S)-4,5-epoxyc...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FTH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50503137(CHEMBL4516990)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human ULK2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at AMPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to PI3Kalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to PI3Kbeta (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mTOR (unknown origin) by lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50503137(CHEMBL4516990)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human ULK1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637405(Capivasertib | Azd 5363 | Azd-5363 | AZC5363 | AZD...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637407(Osi 027 | Osi-027 | AEVI-006 | ASP 7486 | ASP-7486...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PIK3C3 using PI as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637405(Capivasertib | Azd 5363 | Azd-5363 | AZC5363 | AZD...)
Affinity DataIC50: 8nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 8nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637405(Capivasertib | Azd 5363 | Azd-5363 | AZC5363 | AZD...)
Affinity DataIC50: 8nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637406(CHEMBL4744680)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human ULK1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50021398(NSC-93360 | CHEBI:18088 | FORMONONETIN)
Affinity DataKi:  10nMAssay Description:Binding affinity to BCL2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTestis-expressed protein 264(Homo sapiens)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637410(CHEMBL1896972)
Affinity DataIC50: 10nMAssay Description:Inhibition of TEX264 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50: 13nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ULK1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM527983(US11179399, Example 25_2)
Affinity DataIC50: 14nMAssay Description:Inhibition of human PIK3C3 using PI as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTestis-expressed protein 264(Homo sapiens)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50571782(CHEMBL4861569)
Affinity DataIC50: 15nMAssay Description:Inhibition of TEX264 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50092783(CHEMBL3586404)
Affinity DataIC50: 16nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50156294(CHEMBL3781415)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PIK3C3 using PI as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50197067(CHEMBL3913746)
Affinity DataIC50: 25nMAssay Description:Inhibition of human PIK3C3 using PI as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataKi:  26nMAssay Description:Binding affinity to AMPK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50085411(3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylid...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human ULK1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637406(CHEMBL4744680)
Affinity DataIC50: 30nMAssay Description:Inhibition of human ULK2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPatatin-like phospholipase domain-containing protein 2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50637409(NUCIFERINE)
Affinity DataKi:  31nMAssay Description:Inhibition of ATGL ubiquitination in human HepG2 cells assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50084980((2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chr...)
Affinity DataKi:  32nMAssay Description:Binding affinity to FLT3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50111572(CHEMBL3605057)
Affinity DataIC50: 45nMAssay Description:Inhibition of human ULK1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRAC-gamma serine/threonine-protein kinase(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Affinity DataIC50: 65nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFUN14 domain-containing protein 1(Homo sapiens)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50346601(Oleanolic acid (OA)(Compound 1) | NSC-114945 | OLE...)
Affinity DataKi:  72nMAssay Description:Binding affinity to FUNDC1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50387298(CHEMBL2048872)
Affinity DataKi:  80nMAssay Description:Binding affinity to BCL2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM379177(US10266549, Example 88 | US10266549, Example 171a ...)
Affinity DataIC50: 108nMAssay Description:Inhibition of human AMPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50262685(CHEMBL478629 | 6-(4-(2-(piperidin-1-yl)ethoxy)phen...)
Affinity DataKi:  109nMAssay Description:Binding affinity to AMPK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
China Jiliang University

Curated by ChEMBL
LigandPNGBDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human mTORC1 incubated for 90 mins by Lanthascreen time-resolved FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataKd:  170nMAssay Description:Binding affinity to PI3Kalpha (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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