Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50021155
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637554(CHEMBL5560909)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637562(CHEMBL5560152)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using H4 peptide as substrate incubated for 25 mins in presence of [3H]-SAM by liquid scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM486488(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637570(CHEMBL5562317)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full-length PRMT7 (unknown origin) expressed in Sf9 cells using biotinylated H2B as substrate incubated for 60 mins in presence of 3H-S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637569(CHEMBL5562211)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full-length PRMT7 (unknown origin) expressed in Sf9 cells using biotinylated H2B as substrate incubated for 60 mins in presence of 3H-S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637554(CHEMBL5560909)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637558(CHEMBL5523577)
Affinity DataIC50: 3nMAssay Description:Inhibition of flag-tagged PRMT4 (2 to 585 residues) (unknown origin) expressed in HEK293F cells preincubated for 30 mins followed by biotinylated sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT6 (unknown origin) in presence of [3H-SAM] by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of PRMT8 (unknown origin) in presence of [3H-SAM] by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637545(CHEMBL5532081)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 6nMAssay Description:Inhibition of flag-tagged PRMT4 (2 to 585 residues) (unknown origin) expressed in HEK293F cells preincubated for 30 mins followed by biotinylated sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM395024(US10307413, Compound 687)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637561(CHEMBL5567802)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 9(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637563(CHEMBL5558016)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT4 (unknown origin) using biotinylated peptide substrate in presence of SAM by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50636218(CHEMBL5559689)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM415556(US10428104, Example 87)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using H4 peptide as substrate incubated for 25 mins in presence of [3H]-SAM by liquid scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM542512((S)-6-((1-acetylpiperidin-4-yl)amino)-N-(2-hydroxy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PRMT5 expressed in HEK293 cells coexpressing MEP50 incubated for 60 mins by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM486482(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 18nMAssay Description:Inhibition of PRMT4 in human RPMI-8226 cells assessed as reduction in SMB methylation incubated for 96 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637553(CHEMBL5556262)
Affinity DataIC50: 18nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50525230(CHEMBL4461883)
Affinity DataIC50: 21nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM177922(US9675614, 166 | US10307413, Compound 337 | US1039...)
Affinity DataIC50: 22nMAssay Description:Inhibition of PRMT5 (unknown origin) using histone H4 as substrate preincubated for 30 mins followed by SAM addition and measured after 120 mins by T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637560(CHEMBL5567845)
Affinity DataIC50: 23nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637567(CHEMBL5561919)
Affinity DataIC50: 26nMAssay Description:Inhibition of full-length PRMT5 (unknown origin) expressed in insect cells coexpressing 6His-tagged MEP50 using histone H4 peptide as substrate incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637559(CHEMBL5556437)
Affinity DataIC50: 30nMAssay Description:Inhibition of PRMT4 (unknown origin) using H3 peptide in presence of [3H-Me]-SAM preincubated for 30 mins followed by substrate and cofactor addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637563(CHEMBL5558016)
Affinity DataIC50: 30nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 38nMAssay Description:Inhibition of PRMT4 in human RPMI-8226 cells assessed as reduction in PABP1 methylation incubated for 96 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598001(CHEMBL5196058)
Affinity DataIC50: 43nMAssay Description:Inhibition of PRMT4 (unknown origin) using H3 peptide in presence of [3H-Me]-SAM preincubated for 30 mins followed by substrate and cofactor addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 43nMAssay Description:Inhibition of PRMT4 in HEK293 cells assessed as reduction in MED12 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637557(CHEMBL5532598)
Affinity DataIC50: 46nMAssay Description:Inhibition of flag-tagged PRMT4 (2 to 585 residues) (unknown origin) expressed in HEK293F cells preincubated for 30 mins followed by biotinylated sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM486489(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataIC50: 57nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637555(CHEMBL5561740)
Affinity DataIC50: 90nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 9(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637563(CHEMBL5558016)
Affinity DataIC50: 145nMAssay Description:Inhibition of PRMT9 methylation (unknown origin) by in-cell Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598011(CHEMBL5203516)
Affinity DataIC50: 200nMAssay Description:Inhibition of human PRMT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637566(CHEMBL5559832)
Affinity DataIC50: 202nMAssay Description:Inhibition of full-length PRMT5 (unknown origin) expressed in insect cells coexpressing 6His-tagged MEP50 using histone H4 peptide as substrate incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637570(CHEMBL5562317)
Affinity DataIC50: 294nMAssay Description:Inhibition of PRMT7 (unknown origin) assessed as reduction in HSPA8 methylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM343707(US9777008, Compound 1)
Affinity DataIC50: 326nMAssay Description:Inhibition of PRMT5 (unknown origin) using histone H4 as substrate preincubated for 30 mins followed by SAM addition and measured after 120 mins by T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50238601(CHEMBL4074067)
Affinity DataIC50: 330nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: 340nMAssay Description:Inhibition of PRMT4 in HEK293 cells assessed as reduction in BAF155 methylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637564(CHEMBL5563993)
Affinity DataIC50: 430nMAssay Description:Inhibition of PRMT4 (unknown origin) using histone H3 as substrate in presence of 3H-SAM incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637564(CHEMBL5563993)
Affinity DataIC50: 450nMAssay Description:Inhibition of p300 (unknown origin) using histone H3 as substrate in presence of [acetyl-3H]-acetyl-CoAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637565(CHEMBL5560405)
Affinity DataIC50: 460nMAssay Description:Inhibition of p300 (unknown origin) using histone H3 as substrate in presence of [acetyl-3H]-acetyl-CoAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM486483(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataIC50: 482nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637563(CHEMBL5558016)
Affinity DataIC50: 519nMAssay Description:Inhibition of PRMT5 methylation (unknown origin) by in-cell Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50114642(5-(4-chlorophenyl)-2-furaldehyde semicarbazone | C...)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant human PRMT5 (2 to 637 residues) incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637565(CHEMBL5560405)
Affinity DataIC50: 790nMAssay Description:Inhibition of PRMT4 (unknown origin) using histone H3 as substrate in presence of 3H-SAM incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50294572(5'-(Aminopropylthio)-5'-deoxy-adenosine | (2R,3R,4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length PRMT7 (unknown origin) expressed in Sf9 cells using biotinylated H2B as substrate incubated for 60 mins in presence of 3H-S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50194755(CHEMBL3897536)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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