Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50022115
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM287851(US10086000, Example 68 | 8-morpholin-4-yl-6- (6,7,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate preincubated for 30 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50625487(CHEMBL4565370)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50451930(CHEMBL4208002)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal Strep tagged/TEC fused human IDH1 R132H mutant extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Sterp-II tagged recombinant human full length IDH1 R132C mutant extracted from Escherichia coli using alpha-ketoglutarate as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Sterp-II tagged recombinant human full length IDH1 R132H mutant extracted from Escherichia coli using alpha-ketoglutarate as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50625487(CHEMBL4565370)
Affinity DataIC50: 15nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM247859(US9688672, Example 466 | US9434719, 466 | US101129...)
Affinity DataIC50: 18nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648278(CHEMBL5613488)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human IDH1 R132C mutant extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648277(CHEMBL5612245)
Affinity DataEC50:  84nMAssay Description:Inhibition of IDH1 R132C mutant in human HT-1080 cells assessed as reduction in 2-HG level incubated for 48 hrs in presence of NAD+ by resazurin fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648278(CHEMBL5613488)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human IDH1 R132H mutant extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648277(CHEMBL5612245)
Affinity DataIC50: 96nMAssay Description:Inhibition of recombinant human IDH1 R132C mutant extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648277(CHEMBL5612245)
Affinity DataIC50: 124nMAssay Description:Inhibition of recombinant human IDH1 R132H mutant extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648277(CHEMBL5612245)
Affinity DataEC50:  182nMAssay Description:Inhibition of IDH1 R132H mutant in human U-87 MG cells assessed as reduction in 2-HG level incubated for 48 hrs in presence of NAD+ by resazurin fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50451930(CHEMBL4208002)
Affinity DataIC50: 259nMAssay Description:Inhibition of N-terminal Strep tagged/TEC fused human IDH1 R132C mutant extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648278(CHEMBL5613488)
Affinity DataEC50:  263nMAssay Description:Inhibition of IDH1 R132H mutant in human U-87 MG cells assessed as reduction in 2-HG level incubated for 48 hrs in presence of NAD+ by resazurin fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648278(CHEMBL5613488)
Affinity DataEC50:  279nMAssay Description:Inhibition of IDH1 R132C mutant in human HT-1080 cells assessed as reduction in 2-HG level incubated for 48 hrs in presence of NAD+ by resazurin fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648277(CHEMBL5612245)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human wildtype IDH1 extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM166684(4-{3-[(3,4-dihydroxylphenyl)methyl]-2-methylbutyl}...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human wildtype IDH1 extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated for 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50241244(kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human wildtype IDH1 extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated for 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648276(CHEMBL1231518)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human wildtype IDH1 extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50648278(CHEMBL5613488)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human wildtype IDH1 extracted from Escherichia coli BL21 (DE3) cells using alpha-ketoglutarate as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed