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Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50021574
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11554((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCollagenase 3(Human)TBA
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi: <2.10nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCollagenase 3(Human)TBA
LigandPNGBDBM11554((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...)
Affinity DataKi:  3nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi: <3.30nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCollagenase 3(Human)TBA
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi: <5nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCollagenase 3(Human)TBA
LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi: <5nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM11554((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50484351(CHEMBL1835923)
Affinity DataKi:  20nMAssay Description:Inhibition of HIV-1 protease using Val-Ser-Gln-Asn-(beta-naphthylalanine)-Pro-Ile-Val as substrate preincubated with enzyme followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222186(6-(Dimethylamino)-3-(4'-nitrophenyl)-2,3-dihyd...)
Affinity DataIC50: 110nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222179(6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222188(6-(Dimethylamino)-3-(4'-hydroxy-3'-methoxy...)
Affinity DataIC50: 200nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50642085(CHEMBL5572473)
Affinity DataKi:  260nMAssay Description:Inhibition of HIV-1 protease using Val-Ser-Gln-Asn-(beta-naphthylalanine)-Pro-Ile-Val as substrate preincubated with enzyme followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222189(6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxy...)
Affinity DataIC50: 270nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222185(6-(Dimethylamino)-3-(3',5'-dichloro-2-hydr...)
Affinity DataIC50: 270nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222190(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Affinity DataIC50: 300nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222187(6-(Dimethylamino)-3-(2'-methoxyphenyl)-2,3-dih...)
Affinity DataIC50: 310nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInterstitial collagenase(Human)TBA
LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi:  318nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50589183(CHEMBL5180158)
Affinity DataKi:  360nMAssay Description:Inhibition of HIV-1 protease using Val-Ser-Gln-Asn-(beta-naphthylalanine)-Pro-Ile-Val as substrate preincubated with enzyme followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222185(6-(Dimethylamino)-3-(3',5'-dichloro-2-hydr...)
Affinity DataIC50: 380nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222180(6-(Dimethylamino)-3-(4'-dichlorophenyl)-2,3-di...)
Affinity DataIC50: 420nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222191(6-(Dimethylamino)-3-(5'-bromo-2'-hydroxy-3...)
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222181(6-(Dimethylamino)-3-(4'-methylphenyl)-2,3-dihy...)
Affinity DataIC50: 460nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222182(6-(Dimethylamino)-3-(4'-hydroxyphenyl)-2,3-dih...)
Affinity DataIC50: 500nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222192(6-(Dimethylamino)-3-(2',3',4'-trimetho...)
Affinity DataIC50: 510nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222191(6-(Dimethylamino)-3-(5'-bromo-2'-hydroxy-3...)
Affinity DataIC50: 680nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInterstitial collagenase(Human)TBA
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  938nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInterstitial collagenase(Human)TBA
LigandPNGBDBM11554((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...)
Affinity DataKi:  1.09E+3nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222179(6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222192(6-(Dimethylamino)-3-(2',3',4'-trimetho...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222184(6-(Dimethylamino)-3-(3'-nitrophenyl)-2,3-dihyd...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222189(6-(Dimethylamino)-3-(3'-hydroxy-4'-methoxy...)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)TBA
LigandPNGBDBM50642096(CHEMBL5572430)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642100(CHEMBL5567559)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInterstitial collagenase(Human)TBA
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.17E+3nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642092(CHEMBL5564673)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642097(CHEMBL5571578)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)TBA
LigandPNGBDBM50642099(CHEMBL5565592)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642094(CHEMBL5594792)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM222190(6-(Dimethylamino)-3-(3'-bromo-4'-methoxyph...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)TBA
LigandPNGBDBM50642097(CHEMBL5571578)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642098(CHEMBL5575347)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)TBA
LigandPNGBDBM50642095(CHEMBL5566307)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)TBA
LigandPNGBDBM50642092(CHEMBL5564673)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642095(CHEMBL5566307)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50642099(CHEMBL5565592)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
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