Compile Data Set for Download or QSAR
Report error Found 97 Enz. Inhib. hit(s) with all data for entry = 50022681
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021574BDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 0.0300nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592501BDBM50592501(CHEMBL3966821)
Affinity DataKi:  0.220nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592497BDBM50592497(CHEMBL6144831)
Affinity DataKi:  0.300nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lck(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13268BDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 0.400nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetTyrosine-protein kinase Yes(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13268BDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 0.5nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetTyrosine-protein kinase Blk(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357312BDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13268BDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 0.5nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592502BDBM50592502(CHEMBL3938361)
Affinity DataKi:  0.660nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50428286BDBM50428286(GSK2118436A | DABRAFENIB)
Affinity DataIC50: 0.700nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357312BDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.800nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13268BDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 1nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50314074BDBM50314074(2,6,9-Trisubstitute purine, 6 (AP23464) | CHEMBL10...)
Affinity DataIC50: 1nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1.20nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021574BDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 1.30nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25117BDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 1.60nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25117BDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 1.70nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50363397BDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 2.5nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 2.70nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50362781BDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 2.90nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 3.40nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50363397BDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 4.20nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592500BDBM50592500(CHEMBL3915562)
Affinity DataKi:  4.5nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50362781BDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13268BDBM13268(CHEMBL364623 | N-(2-Chloro-6-methylphenyl)-2-[(2,6...)
Affinity DataIC50: 5nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50102093BDBM50102093(6,7-dimethoxy-N-m-tolylquinazolin-4-amine | (6,7-D...)
Affinity DataIC50: 5nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357312BDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 5.60nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataIC50: 6nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391802BDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 6.60nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592507BDBM50592507(CHEMBL1807711)
Affinity DataIC50: 7nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCyclin-dependent kinase 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6310BDBM6310(8-Cyclopentyl-5-methyl-7-oxo-2-(5-piperazin-1-yl-p...)
Affinity DataIC50: 10nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357312BDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 10nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4524BDBM4524(4-[(2-chloro-5-methoxyphenyl)amino]-6,7-dimethoxyq...)
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCyclin-dependent kinase 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6302BDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50: 11nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322823BDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 14nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4813BDBM4813(N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-{[(3Z)-2-...)
Affinity DataIC50: 17nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataIC50: 20nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50363397BDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 22nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5447BDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16673BDBM16673(BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-c...)
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 30nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4492BDBM4492(CHEMBL101917 | 4-[(2,4-dichlorophenyl)amino]-6,7-d...)
Affinity DataIC50: 30nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50362781BDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 32nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595124BDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 44nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4813BDBM4813(N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-{[(3Z)-2-...)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133384BDBM50133384(N4-(3-methylphenyl)-4,6-quinazolinediamine | Anili...)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4813BDBM4813(N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-{[(3Z)-2-...)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294016BDBM50294016((E)-N-(4-Methyl-3-(2-(6-(methylamino)-9Hpurin-9-yl...)
Affinity DataIC50: 52nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50362781BDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 53nMAssay Description:Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
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