Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50023484
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664142BDBM50664142(CHEMBL6147825)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of pERK in human ASPC1 cells by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50242325BDBM50242325(CHEMBL4072295)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of KRas G12D mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664142BDBM50664142(CHEMBL6147825)
Affinity DataIC50: 2nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597280BDBM50597280(CHEMBL5189659)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of KRas G12D mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664147BDBM50664147(CHEMBL6173824)
Affinity DataIC50: 11nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664148BDBM50664148(CHEMBL6172941)
Affinity DataIC50: 16nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664140BDBM50664140(CHEMBL6169982)
Affinity DataIC50: 18nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664139BDBM50664139(CHEMBL6169752)
Affinity DataEC50:  22nMAssay Description:Inhibition of human KRas G12D mutant incubated for 0.5 hrs by absorbance based analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664154BDBM50664154(CHEMBL6168907)
Affinity DataIC50: 23nMAssay Description:Inhibition of KRas (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664143BDBM50664143(CHEMBL6169335)
Affinity DataIC50: 24nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664145BDBM50664145(CHEMBL6172930)
Affinity DataIC50: 36nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597280BDBM50597280(CHEMBL5189659)
Affinity DataKd:  51nMAssay Description:Binding affinity to KRas G12D mutant (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664146BDBM50664146(CHEMBL5590086)
Affinity DataIC50: 54nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664143BDBM50664143(CHEMBL6169335)
Affinity DataIC50: 110nMAssay Description:Inhibition of pERK in human ASPC1 cells by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664141BDBM50664141(CHEMBL6171789)
Affinity DataIC50: 110nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664144BDBM50664144(CHEMBL6143155)
Affinity DataIC50: 120nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664136BDBM50664136(CHEMBL6161405)
Affinity DataEC50:  172nMAssay Description:Inhibition of GDP bound KRas G12D mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664159BDBM50664159(CHEMBL6162571)
Affinity DataKd:  210nMAssay Description:Binding affinity to KRas (unknown origin) assessed as apparent dissociation constant by fluorescence anisotropy analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664147BDBM50664147(CHEMBL6173824)
Affinity DataIC50: 230nMAssay Description:Inhibition of pERK in human ASPC1 cells by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421182BDBM50421182(CHEMBL2086797)
Affinity DataIC50: 640nMAssay Description:Inhibition of KRAS G12D mutant/SOS1 (unknown origin) interaction by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664148BDBM50664148(CHEMBL6172941)
Affinity DataIC50: 870nMAssay Description:Inhibition of pERK in human ASPC1 cells by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664138BDBM50664138(CHEMBL6151103)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of pERK in human ASPC1 cells measured after 1 hrMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664149BDBM50664149(CHEMBL6163006)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to GTP bound KRas (unknown origin) assessed as dissociation constant by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664138BDBM50664138(CHEMBL6151103)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of pERK in human ASPC1 cells measured after 18 hrMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664149BDBM50664149(CHEMBL6163006)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to GppNHp bound KRas (unknown origin) assessed as dissociation constant by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase HRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664153BDBM50664153(CHEMBL6165011)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to HRas (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664137BDBM50664137(CHEMBL6150089)
Affinity DataEC50:  3.60E+3nMAssay Description:Inhibition of pERK in human ASPC1 cells measured after 1 hrMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664148BDBM50664148(CHEMBL6172941)
Affinity DataKd:  3.92E+3nMAssay Description:Binding affinity to KRas (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase HRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664148BDBM50664148(CHEMBL6172941)
Affinity DataKd:  3.92E+3nMAssay Description:Binding affinity to HRas (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase HRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664150BDBM50664150(CHEMBL6149416)
Affinity DataKd:  4.10E+3nMAssay Description:Binding affinity to wild-type H-Ras (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664151BDBM50664151(CHEMBL6161358)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRas G12S mutant (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664151BDBM50664151(CHEMBL6161358)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant wild-type KRas (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664151BDBM50664151(CHEMBL6161358)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRas G12D mutant (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664151BDBM50664151(CHEMBL6161358)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRas G12V mutant (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664151BDBM50664151(CHEMBL6161358)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRas G12C mutant (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664158BDBM50664158(CHEMBL6172769)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to KRas G12V mutant (unknown origin) assessed as dissociation constant fluorescence anisotropy analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421182BDBM50421182(CHEMBL2086797)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of his-tagged N-terminal GDP-bound KRas (1 to 166 residues)/his-tagged catalytic domain SOS (564 to 1049 residues) (unknown origin) intera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664156BDBM50664156(CHEMBL6164813)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of KRas (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664152BDBM50664152(CHEMBL6165137)
Affinity DataKd:  7.67E+3nMAssay Description:Binding affinity to KRas G12C mutant (unknown origin) assessed as dissociation constant by biolayer interferometry assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664157BDBM50664157(CHEMBL6164179)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of KRas (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664159BDBM50664159(CHEMBL6162571)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to KRas G12V mutant (unknown origin) assessed as apparent dissociation constant by fluorescence anisotropy analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421182BDBM50421182(CHEMBL2086797)
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to his-tagged N-terminal KRas (1 to 166 residues)/his-tagged catalytic domain SOS (564 to 1049 residues) (unknown origin) interactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEphrin type-B receptor 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664137BDBM50664137(CHEMBL6150089)
Affinity DataEC50:  3.05E+4nMAssay Description:Inhibition of pERK in human ASPC1 cells measured after 18 hrMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664155BDBM50664155(CHEMBL6148864)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KRas (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50421182BDBM50421182(CHEMBL2086797)
Affinity DataKd:  1.58E+5nMAssay Description:Binding affinity to his-tagged N-terminal GDP-bound KRas (1 to 166 residues)/his-tagged catalytic domain SOS (564 to 1049 residues) (unknown origin) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed