Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50022848
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655040BDBM50655040(CHEMBL6171065)
Affinity DataIC50: 160nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655040BDBM50655040(CHEMBL6171065)
Affinity DataIC50: 360nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044140BDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone(Ke...)
Affinity DataIC50: 500nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044140BDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone(Ke...)
Affinity DataIC50: 510nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062599BDBM50062599(CHEMBL807 | Namenda | 3,5-Dimethyl-adamantan-1-yla...)
Affinity DataIC50: 780nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062599BDBM50062599(CHEMBL807 | Namenda | 3,5-Dimethyl-adamantan-1-yla...)
Affinity DataIC50: 840nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655041BDBM50655041(CHEMBL6145347)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655041BDBM50655041(CHEMBL6145347)
Affinity DataIC50: 4.42E+3nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655040BDBM50655040(CHEMBL6171065)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044140BDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone(Ke...)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of BACE1 (unknown origin) assessed as reduction in Abeta42 level by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetCholinesterase(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655042BDBM50655042(CHEMBL6144980)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of BACE1 (unknown origin) assessed as reduction in Abeta42 level by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655040BDBM50655040(CHEMBL6171065)
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062599BDBM50062599(CHEMBL807 | Namenda | 3,5-Dimethyl-adamantan-1-yla...)
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of BACE1 (unknown origin) assessed as reduction in Abeta42 level by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062599BDBM50062599(CHEMBL807 | Namenda | 3,5-Dimethyl-adamantan-1-yla...)
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044140BDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone(Ke...)
Affinity DataIC50: 5.33E+4nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655041BDBM50655041(CHEMBL6145347)
Affinity DataIC50: 2.15E+5nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655041BDBM50655041(CHEMBL6145347)
Affinity DataIC50: 2.76E+5nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed