Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50036249
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038840BDBM50038840((4R)-2-[(4-bromo-2-fluorophenyl)methyl]-2,3-dihydr...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 12.2nMAssay Description:Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038843BDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038858BDBM50038858(2-(1,3-benzothiazol-2-ylmethyl)-1H,2'H,5'H-spiro[i...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038851BDBM50038851(2-[3-(trifluoromethyl)benzyl]-1H,2'H,5'H-spiro[iso...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038842BDBM50038842(2-(1,3-benzothiazol-2-ylmethyl)-6-fluoro-1H,2'H,5'...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038839BDBM50038839(2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydro...)
Affinity DataIC50: 19nMAssay Description:Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038844BDBM50038844(2-(4-bromo-2-fluorobenzyl)-7-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038856BDBM50038856(2-(4-bromo-2-fluorobenzyl)-5-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 21nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038862BDBM50038862(2-(4-chlorobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038853BDBM50038853(2-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]meth...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038838BDBM50038838(2-(3,4-dichlorobenzyl)-1H,2'H,5'H-spiro[isoquinoli...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038852BDBM50038852(2-(4-bromobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4,...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038857BDBM50038857(2-(4-bromo-2-fluorobenzyl)-8-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038839BDBM50038839(2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydro...)
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16314BDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 24nMAssay Description:Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038849BDBM50038849(2-(3-methylbenzyl)-1H,2'H,5'H-spiro[isoquinoline-4...)
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038861BDBM50038861(2-[4-(trifluoromethyl)benzyl]-1H,2'H,5'H-spiro[iso...)
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038854BDBM50038854(2-(4-methoxybenzyl)-1H,2'H,5'H-spiro[isoquinoline-...)
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038846BDBM50038846(6-fluoro-2-(5-trifluoromethylbenzo[d][1,3]thiazol-...)
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038863BDBM50038863(6-bromo-2-(4-bromo-2-fluorobenzyl)-7-methoxy-1H,2'...)
Affinity DataIC50: 28nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038845BDBM50038845(2-(4-bromo-2-fluorobenzyl)-5-fluoro-6-methoxy-1H,2...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038841BDBM50038841(2-(4-bromo-2-fluorobenzyl)-6-chloro-1H,2'H,5'H-spi...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038859BDBM50038859((4S)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-2...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038848BDBM50038848(2-(4-bromo-2-fluorobenzyl)-7-chloro-1H,2'H,5'H-spi...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16314BDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038860BDBM50038860(2-(4-bromo-2-fluorobenzyl)-7-methoxy-1H,2'H,5'H-sp...)
Affinity DataIC50: 37nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038855BDBM50038855(2-(4-bromo-2-fluorobenzyl)-6-(trifluoromethyl)-1H,...)
Affinity DataIC50: 38nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038850BDBM50038850((4S)-2-[(4-bromo-2-fluorophenyl)methyl]-2,3-dihydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed