Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50036197
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50368782BDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031890BDBM50031890(17-tert-Butylcarbamoyl-10,13-dimethyl-2,7,8,9,10,1...)
Affinity DataIC50: 8nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334788BDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50: 10nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH).More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044878BDBM50044878(4,8-Dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]q...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044879BDBM50044879((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044881BDBM50044881(8-Chloro-4-methyl-1,4,5,6-tetrahydro-2H-benzo[f]qu...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044891BDBM50044891(8-Fluoro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benz...)
Affinity DataIC50: 35nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044885BDBM50044885(8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benz...)
Affinity DataIC50: 41nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044886BDBM50044886(8-Chloro-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quino...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334788BDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50: 62nMAssay Description:Compound was tested for inhibition of Type I 5-alpha-reductase in Human genital skin (Hs68) foreskin fibroblast cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044893BDBM50044893(8-Chloro-4,10b-dimethyl-1,4,6,10b-tetrahydro-2H-be...)
Affinity DataIC50: 120nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044892BDBM50044892(8-Methoxy-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-ben...)
Affinity DataIC50: 120nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044877BDBM50044877(8-Fluoro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benz...)
Affinity DataIC50: 320nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044890BDBM50044890(8-Chloro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50: 460nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044876BDBM50044876(4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quino...)
Affinity DataIC50: 560nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044880BDBM50044880(8-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044888BDBM50044888(8-Chloro-10b-methyl-1,4,4a,5,6,10b-hexahydro-2H-be...)
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044894BDBM50044894(9-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50: 2.30E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044883BDBM50044883(7-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50: 3.20E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044887BDBM50044887(8-Chloro-10b-methyl-1,4,6,10b-tetrahydro-2H-benzo[...)
Affinity DataIC50: 3.60E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044889BDBM50044889(1,4,5,6-Tetrahydro-2H-benzo[f]quinolin-3-one | CHE...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031890BDBM50031890(17-tert-Butylcarbamoyl-10,13-dimethyl-2,7,8,9,10,1...)
Affinity DataIC50: 7.50E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50368782BDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044884BDBM50044884(10-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed