Compile Data Set for Download or QSAR
Report error Found 1714 Enz. Inhib. hit(s) with all data for entry = 12484
TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705875(US20160046618, Example 1001)
Affinity DataIC50: 0.0590nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705874((1S,5S,6S)-3-amino-5-(2-fluoro-5-(5-(2,2,2-trifluo...)
Affinity DataIC50: 0.0700nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705873((1S,5S,6S)-3-amino-N-(2,2-difluoroethyl)-5-(2-fluo...)
Affinity DataIC50: 0.0900nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705833(US20160046618, Example 959)
Affinity DataIC50: 0.0900nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705878(N-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-...)
Affinity DataIC50: 0.100nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705841(US20160046618, Example 967)
Affinity DataIC50: 0.110nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705861(US20160046618, Example 987)
Affinity DataIC50: 0.140nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705872(N-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-...)
Affinity DataIC50: 0.146nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705631((E)-3-((1R,5S,6S)-3-amino-5-(5-(5-chloropicolinami...)
Affinity DataIC50: 0.176nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705942(US20160046618, Example 1068)
Affinity DataIC50: 0.178nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705837(US20160046618, Example 963)
Affinity DataIC50: 0.194nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705843(US20160046618, Example 969)
Affinity DataIC50: 0.197nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705793(US20160046618, Example 919)
Affinity DataIC50: 0.199nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705794(US20160046618, Example 920)
Affinity DataIC50: 0.201nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705712(US20160046618, Example 838)
Affinity DataIC50: 0.209nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705654(US20160046618, Example 780)
Affinity DataIC50: 0.220nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705679(US20160046618, Example 805)
Affinity DataIC50: 0.222nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM50510977(CHEMBL4577527 | US20160046618, Example 807)
Affinity DataIC50: 0.228nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705739(US20160046618, Example 865)
Affinity DataIC50: 0.236nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705690(US20160046618, Example 816)
Affinity DataIC50: 0.244nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705798(US20160046618, Example 924)
Affinity DataIC50: 0.249nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705939(US20160046618, Example 1065)
Affinity DataIC50: 0.256nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705696(US20160046618, Example 822)
Affinity DataIC50: 0.264nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705891((1S,5S,6S)-3-amino-N-ethyl-5-(2-fluoro-5-(5-(prop-...)
Affinity DataIC50: 0.266nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705801(US20160046618, Example 927)
Affinity DataIC50: 0.266nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705684(N-(3-((1S,5S,6S)-3-amino-1,5-bis(fluoromethyl)-2-t...)
Affinity DataIC50: 0.268nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705651(US20160046618, Example 777)
Affinity DataIC50: 0.274nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705538(US20160046618, Example 664)
Affinity DataIC50: 0.274nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705859((1S,5S,6S)-3-amino-5-(5-(5-chloropicolinamido)-2-f...)
Affinity DataIC50: 0.276nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705827(US20160046618, Example 953)
Affinity DataIC50: 0.280nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705618(US20160046618, Example 744)
Affinity DataIC50: 0.290nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705667(US20160046618, Example 793)
Affinity DataIC50: 0.293nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705672(US20160046618, Example 798)
Affinity DataIC50: 0.294nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705865(N-(3-((1S,5S,6S)-3-amino-1-((R)-3-fluoropyrrolidin...)
Affinity DataIC50: 0.297nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705669(US20160046618, Example 795)
Affinity DataIC50: 0.300nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705427(US20160046618, Example 61)
Affinity DataIC50: 0.300nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM50510987(CHEMBL4472708 | US20160046618, Example 913)
Affinity DataIC50: 0.303nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705648(US20160046618, Example 774)
Affinity DataIC50: 0.313nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705853(US20160046618, Example 979)
Affinity DataIC50: 0.315nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705757(US20160046618, Example 883)
Affinity DataIC50: 0.316nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705916(N-(3-((1S,5S,6S)-1-(acetamidomethyl)-3-amino-5-met...)
Affinity DataIC50: 0.317nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705658(N-(3-((1S,5S,6S)-3-amino-5-(fluoromethyl)-1-(4-met...)
Affinity DataIC50: 0.318nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705694(US20160046618, Example 820)
Affinity DataIC50: 0.319nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705623(US20160046618, Example 749)
Affinity DataIC50: 0.319nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705478(N-(5-((1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl...)
Affinity DataIC50: 0.320nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705945(US20160046618, Example 1072)
Affinity DataIC50: 0.320nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705664(US20160046618, Example 790)
Affinity DataIC50: 0.338nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705852((1S,5S,6S)-3-amino-5-(5-(5-((S)-but-3-yn-2-yloxy)p...)
Affinity DataIC50: 0.344nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705917(US20160046618, Example 1043)
Affinity DataIC50: 0.352nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705507(US20160046618, Example 633)
Affinity DataIC50: 0.360nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

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